68521-88-0
基本信息
血管緊縮素 II
人血管緊縮素II
血管緊張素 II 醋酸鹽
人血管緊縮素II(-20℃)
ANGIOTENSIN II HUMAN 乙酸鹽
ANGIOTENSIN , HUMAN
Angiotensin Ⅱ, human
ANGIOTENSIN II ACETATE SALT
ANGIOTENSIN II ACETATE HUMAN
angiotensin ii human acetate
ANGIOTENSIN II, HUMAN, SYNTHETIC
ANGIOTENSIN II HUMAN ACETATE SALT
Human angiotensin II acetate salt
ANGIOTENSIN II, MASS SPEC STANDARD
常見問題列表
Most of the known actions of Angiotensin II (Ang II) are mediated by AT 1 receptors, the AT 2 receptor contributes to the regulation of blood pressure and renal function. Angiotensin II raises blood pressure (BP) by a number of actions, the most important ones being vasoconstriction, sympathetic nervous stimulation, increased aldosterone biosynthesis and renal actions. Other Angiotensin II actions include induction of growth, cell migration, and mitosis of vascular smooth muscle cells, increased synthesis of collagen type I and III in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. These actions are mediated by type 1 Ang II receptors (AT 1 ). At the cellular level, responsiveness to Angiotensin II is conferred by the expression of the two classes of angiotensin receptors (AT 1 and AT 2 ). The effects of Angiotensin II to increase blood pressure are mediated by AT1 receptors.
To distinguish the AT 1 receptor population that is critical for the pathogenesis of hypertension, osmotic minipumps are implanted s.c. into each animal to infuse Angiotensin II (1,000 ng/kg/min) continuously for 4 weeks. Angiotensin II causes hypertension by activating AT 1 receptors in the kidney promoting sodium reabsorption.