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68521-88-0

中文名稱 血管緊張素II
英文名稱 ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE ACETATE SALT
CAS 68521-88-0
分子式 C52H75N13O14
分子量 1106.25
MOL 文件 68521-88-0.mol
更新日期 2024/12/16 11:45:46
68521-88-0 結(jié)構式 68521-88-0 結(jié)構式

基本信息

中文別名
血管緊縮素II
血管緊縮素 II
人血管緊縮素II
血管緊張素 II 醋酸鹽
人血管緊縮素II(-20℃)
ANGIOTENSIN II HUMAN 乙酸鹽
英文別名
HYPERTENSIN II
ANGIOTENSIN , HUMAN
Angiotensin Ⅱ, human
ANGIOTENSIN II ACETATE SALT
ANGIOTENSIN II ACETATE HUMAN
angiotensin ii human acetate
ANGIOTENSIN II, HUMAN, SYNTHETIC
ANGIOTENSIN II HUMAN ACETATE SALT
Human angiotensin II acetate salt
ANGIOTENSIN II, MASS SPEC STANDARD
所屬類別
生物化工:多肽

物理化學性質(zhì)

儲存條件−20°C
溶解度H2O: 25 mg/mL, clear, colorless
形態(tài)powder
顏色orange

安全數(shù)據(jù)

WGK Germany3

常見問題列表

生物活性
Angiotensin II (Ang II, DRVYIHPF)是一種八肽激素,能夠影響心血管、腎臟和腦活性。它通過結(jié)合細胞膜上特定受體發(fā)揮作用。
體外研究

Most of the known actions of Angiotensin II (Ang II) are mediated by AT 1 receptors, the AT 2 receptor contributes to the regulation of blood pressure and renal function. Angiotensin II raises blood pressure (BP) by a number of actions, the most important ones being vasoconstriction, sympathetic nervous stimulation, increased aldosterone biosynthesis and renal actions. Other Angiotensin II actions include induction of growth, cell migration, and mitosis of vascular smooth muscle cells, increased synthesis of collagen type I and III in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. These actions are mediated by type 1 Ang II receptors (AT 1 ). At the cellular level, responsiveness to Angiotensin II is conferred by the expression of the two classes of angiotensin receptors (AT 1 and AT 2 ). The effects of Angiotensin II to increase blood pressure are mediated by AT1 receptors.

體內(nèi)研究

To distinguish the AT 1 receptor population that is critical for the pathogenesis of hypertension, osmotic minipumps are implanted s.c. into each animal to infuse Angiotensin II (1,000 ng/kg/min) continuously for 4 weeks. Angiotensin II causes hypertension by activating AT 1 receptors in the kidney promoting sodium reabsorption.

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