68077-27-0
中文名稱(chēng)
鹽酸諾氟沙星
英文名稱(chēng)
Norfloxacinehydrochloride
CAS
68077-27-0
分子式
C16H19ClFN3O3
分子量
355.792
MOL 文件
68077-27-0.mol
更新日期
2023/11/10 17:38:38
68077-27-0 結(jié)構(gòu)式
基本信息
中文別名
NORFL氧雜CIN鹽酸鹽 英文別名
NorfloxacineHClNorfloxacinehydrochloride
Hydrochloric acid and norfloxacin
Norfloxacinehydrochloride USP/EP/BP
所屬類(lèi)別
原料藥：喹諾酮類(lèi)藥常見(jiàn)問(wèn)題列表
生物活性
Norfloxacin hydrochloride (MK-0366 hydrochloride) 是廣譜抗生素，能通過(guò)結(jié)合DNA旋轉(zhuǎn)酶抑制革蘭氏陽(yáng)性和陰性菌。靶點(diǎn)
DNA gyrase; Antibacterial.
體外研究
Norfloxacin hydrochloride (MK-0366 hydrochloride) is a synthetic chemotherapeutic antibacterial agent occasionally used to treat common as well as complicated urinary tract infections. Norfloxacin (MK-0366) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. It functions by inhibiting DNA gyrase, a type II topoisomerase, and topoisomerase IV, enzymes necessary to separate bacterial DNA, thereby inhibiting cell division.There are currently three approved uses in the adult population (one of which is restricted) and the other ineffective due to bacterial resistance.