67700-30-5

基本信息
furaprofen USP/EP/BP
7-Benzofuranacetic acid, α-methyl-3-phenyl-
2-(3-phenyl-1-benzofuran-7-yl)propanoic acid
物理化學(xué)性質(zhì)
報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
2025/02/08 | HY-U00213 | 呋喃洛芬 Furaprofen | 67700-30-5 | 1 mg | 2475元 |
2025/02/08 | HY-U00213 | 呋喃洛芬 Furaprofen | 67700-30-5 | 10 mM * 1 mLin DMSO | 7250元 |
2024/08/19 | HY-U00213 | 呋喃洛芬 Furaprofen | 67700-30-5 | 5mg | 8500元 |
常見問題列表
EC50: ~30 nM (HCV genotype 1a and 1b replicons), ~1000 nM (HCV genotype 2a replicon)
Furaprofen (R803) is potent and highly specific for HCV replication. The antiviral activity of Furaprofen has been determined by a reporter replicon assay with multiple repeats to be 29.88±8.05 nM, an ~3-fold improvement over the activity of the parent compound, R706. The potency of Furaprofen against the replicon is also confirmed by both Western blotting and TaqMan RT-PCR to be about 37 nM and 54.67±4.11 nM, respectively. To assess the general effect of Furaprofen on cell proliferation, a panel of primary cells and transformed human cell lines are treated with increasing doses of Furaprofen for 48 h, and the effect on cell proliferation is measured by an MTS-based cell viability assay. The the concentration that caused a 50% reduction in cell numbers in the absence of virus infection (CC 50 ) of Furaprofen is found to range from 2 μM to ≥10 μM, depending on the cell type and proliferation status.