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67700-30-5

中文名稱 呋喃洛芬
英文名稱 furaprofen
CAS 67700-30-5
分子式 C17H14O3
分子量 266.29
MOL 文件 67700-30-5.mol
67700-30-5 結(jié)構(gòu)式 67700-30-5 結(jié)構(gòu)式

基本信息

中文別名
呋喃洛芬
英文別名
furaprofen
furaprofen USP/EP/BP
7-Benzofuranacetic acid, α-methyl-3-phenyl-
2-(3-phenyl-1-benzofuran-7-yl)propanoic acid
所屬類別
原料藥:非甾抗炎藥

物理化學性質(zhì)

沸點449.4±33.0 °C(Predicted)
密度1.230±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)4?+-.0.30(Predicted)
形態(tài)Solid
顏色White to light yellow

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險性描述H302-H315-H319-H335

常見問題列表

生物活性
Furaprofen (R803) 是一種有效的 HCV 復制抑制劑。作用于 HCV 基因型 1a 和 1b 復制子時 EC50 約為 30 nM,作用于基因型 2a 復制子時 EC50 約為 1000 nM。
靶點

EC50: ~30 nM (HCV genotype 1a and 1b replicons), ~1000 nM (HCV genotype 2a replicon)

體外研究

Furaprofen (R803) is potent and highly specific for HCV replication. The antiviral activity of Furaprofen has been determined by a reporter replicon assay with multiple repeats to be 29.88±8.05 nM, an ~3-fold improvement over the activity of the parent compound, R706. The potency of Furaprofen against the replicon is also confirmed by both Western blotting and TaqMan RT-PCR to be about 37 nM and 54.67±4.11 nM, respectively. To assess the general effect of Furaprofen on cell proliferation, a panel of primary cells and transformed human cell lines are treated with increasing doses of Furaprofen for 48 h, and the effect on cell proliferation is measured by an MTS-based cell viability assay. The the concentration that caused a 50% reduction in cell numbers in the absence of virus infection (CC 50 ) of Furaprofen is found to range from 2 μM to ≥10 μM, depending on the cell type and proliferation status.

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