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67684-64-4

中文名稱 (±)-TRANS-ACPD
英文名稱 (+/-)-1-AMINOCYCLOPENTANE-TRANS-1,3-DICARBOXYLIC ACID
CAS 67684-64-4
分子式 C7H11NO4
分子量 173.17
MOL 文件 67684-64-4.mol
67684-64-4 結(jié)構(gòu)式 67684-64-4 結(jié)構(gòu)式

基本信息

中文別名
化合物(±)-TRANS-ACPD
英文別名
TRANS-ACPD
Trans-(±)-ACP
TRANS-(±)-ACPD
TRANS-(+/-)-ACPD
(+/-)-TRANS-ACPD
trans-(±)-ACPD monohydrate
TRANS(+-)-ACPD EXCITATORY AMINO ACID
TRANS-(+/-)-1-AMINO-1,3-CYCLOPENTANEDICARBOXYLIC ACID
(+/-)-1-AMINOCYCLOPENTANE-TRANS-1,3-DICARBOXYLIC ACID
(+/-)-1-Aminocyclopentanl-trans-1,3-Dicarboxylic acid

物理化學性質(zhì)

沸點352.7±42.0 °C(Predicted)
密度1.452±0.06 g/cm3(Predicted)
儲存條件Keep in dark place,Inert atmosphere,2-8°C
溶解度水中的溶解度為1mg/mL
酸度系數(shù)(pKa)2.11±0.40(Predicted)
形態(tài)固體
顏色白色
水溶解性Soluble to 5 mM in water with gentle warming and to 50 mM in 1eq. NaOH

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險性描述H302+H312+H332
危險品標志Xn
危險類別碼20/21/22
WGK Germany3
(±)-TRANS-ACPD價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2025/02/08HY-19434(±)-TRANS-ACPD
trans-ACPD
67684-64-41 mg365元
2025/02/08HY-19434(±)-TRANS-ACPD
trans-ACPD
67684-64-410mM * 1mLin DMSO695元
2025/02/08HY-19434(±)-TRANS-ACPD
trans-ACPD
67684-64-45mg830元

常見問題列表

生物活性
trans-ACPD 是一種代謝型受體激動劑,促進鈣離子活動及產(chǎn)生內(nèi)向電流。
靶點

mGluR

體外研究

Excitatory amino acid (EAA) analogues activate receptors that are coupled to the increased hydrolysis of phosphoinositides (PIs). In these studies, hippocampal slices are prepared from neonatal rats (6-11 days old) to characterize the effects of EAA analogues on these receptors. The concentrations of trans-ACPD required to evoke half-maximal stimulation (EC 50 value) is 51 μM. DL-2-Amino-3-phosphonopropionate (DL-AP3) is also equipotent as an inhibitor of PI hydrolysis stimulated by ibotenate, quisqualate, and trans-ACPD (IC 50 values are 480-850 μM).

體內(nèi)研究

Intrathecal injection of NMDA, kainate, and trans-ACPD, TNF-α, or IL-1β causes significant (p<0.001) biting behaviour in mice compared to animals injected intrathecally with saline. In all groups, systemic pre-treatment with GM (100 mg/kg, i.p.) significantly (p<0.001) reduces the biting behaviour compared to mice treated with saline (10 mL/kg, i.p.). The greatest effect of GM is observed on the pro-inflammatory cytokines and NMDA, with the following inhibition percentages: TNF-α (92±7%), IL-1β (91±5%), NMDA (69±1%), and trans-ACPD (71±12%). By contrast, at the same dose, GM has no significant effect on the kainate-mediated biting response.

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