6736-58-9
基本信息
3-氮雜腺苷
3-脫氮腺苷
3-DEAZA-腺苷
4-氨基-1-BETA-D-呋喃核糖基-1H-咪唑并[4,5-C]吡啶
NSC 167897
3-Deaza-rA
3-DEAZAADENOSINE
3-Deaza-D-adenosine
3-Deazaadenosine ,98%
1-β-D-Ribofuranosyl-1H-imidazo[4,5-c]pyridin-4-amine
4-Amino-1-(D-ribofuranosyl)-1H-imidazo(4,5)-pyridine
4-Amino-1-beta-D-ribofuranosyl-1H-imidazo[4,5-c]pyridine
1H-Imidazo4,5-cpyridin-4-amine, 1-.beta.-D-ribofuranosyl-
物理化學性質
常見問題列表
IC50: 0.15 (HIV-1, A012 isolate), 0.20 μM (HIV-1, A018 isolate)
Ki: 3.9 μM (S-adenosylhomocysteine hydrolase)
3-Deazaadenosine is an inhibitor of S-adenosylhomocysteine hydrolase, with a K i of 3.9 μM. 3-Deazaadenosine shows anti-HIV effect, and inhibits p24 antigen in peripheral blood mononuclear (PBMCs) cells infected with HIV-1 isolates (A012 and A018) with IC 50 s of 0.15 and 0.20 μM, respectively. 3-Deazaadenosine (1-100 μM) inhibits LPS-induced expression of TNF-α mRNA, increases DNA binding activity of NF-κB, and causes proteolytic degradation of IκBα, but Not IκBβ in RAW 264.7 cells. 3-Deazaadenosine (100 μM) enhances nuclear translocation of NF-κB, but blocks LPS-induced NF-κB transcriptional activity, and such inhibition is augmented by the addition of homocysteine. 3-Deazaadenosine (50, 100 μM) dose-dependently inhibits the phosphorylation of Raf and ERK, protein-dependent kinase 1, protein kinase B (Akt), and forkhead transcription factor FoxO1a. 3-Deazaadenosine (50 μM) suppresses vascular smooth muscle cell (VSMC) proliferation via interfering with Ras signaling.