66225-78-3
中文名稱
66225-78-3
英文名稱
2-((4R)-4-((3R,5R,6S,7R,10R,13R)-3,6,7-Trihydroxy-10,13-Dimethylhexadecahydro-1H-Cyclopenta[A]Phenanthren-17-Yl)Pentanamido)Acetic Acid
CAS
66225-78-3
分子式
C26H43NO6
分子量
465.62
MOL 文件
66225-78-3.mol
更新日期
2023/03/20 15:41:21
66225-78-3 結(jié)構(gòu)式
基本信息
中文別名
甘氨酸-多酚酸化合物 T11426
英文別名
Gly-β-MCAGlyco-?-Muricholic Acid
Glycine--Muricholic Acid
Glycine-β-muricholic Acid
Glycine-β-muricholic acid (GβMCA)
N-[(3α,5β,6β,7β)-3,6,7-Trihydroxy-24-oxocholan-24-yl]glycine
2-((4R)-4-((3R,5R,6S,7R,10R,13R)-3,6,7-Trihydroxy-10,13-Dimethylhexadecahydro-1H-Cyclopenta[A]Phenanthren-17-Yl)Pentanamido)Acetic Acid
2-((4R)-4-((3R,5R,6S,7R,10R,13R)-3,6,7-Trihydroxy-10,13-Dimethylhexadecahydro-1H-Cyclopenta[A]Phenanthren-17-Yl)Pentanamido)Acetic Acid(WXC04817)
所屬類別
生物化工：甘氨酸類衍生物物理化學性質(zhì)
沸點673.4±55.0 °C(Predicted)
密度1.213±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度DMF: 30 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml
酸度系數(shù)(pKa)3.58±0.10(Predicted)
形態(tài)結(jié)晶固體
顏色White to off-white
常見問題列表
生物活性
Gly-β-MCA 是一種膽汁酸，是有效的、穩(wěn)定的、腸特異性的以及具有口服生物活性的法尼酯X受體 (FXR) 抑制劑，可用于代謝障礙的研究。靶點
FXR.
體外研究
Gly-β-MCA, a bile acid, is a potent, sable and intestine-selective and farnesoid X receptor (FXR) inhibitor.
Gly-β-MCA (Gly-MCA, ) is resistant to hydrolysis by BSH.
體內(nèi)研究
Gly-β-MCA (Gly-MCA, p.o. 10 and 50 mg/kg) prevents and treats diet-induced and genetic obesity, along with insulin resistance and hepatic steatosis without systemic, hepatic or intestinal toxicities in mice.
Gly-MCA does not increase faecal LCN-2 levels, indicating that Gly-MCA does not induce intestinal inflammation.