63676-22-2
中文名稱
2-(4-羥基苯基)苯并[B]噻吩-6-醇
英文名稱
2-(4-Hydroxyphenyl)benzo[b]thiophene-6-ol
CAS
63676-22-2
分子式
C14H10O2S
分子量
242.293
MOL 文件
63676-22-2.mol
更新日期
2024/12/23 16:06:32
63676-22-2 結(jié)構(gòu)式
基本信息
中文別名
雷洛昔芬雜質(zhì)8雷洛昔芬雜質(zhì)4
2-(4-羥基苯基)苯并[B]噻吩-6-醇
2-(4-羥苯基)-苯并[B]噻吩-6-醇
2-(4-羥苯基)苯并[B]噻吩-6-醇
英文別名
Raloxifene Impurity 4Raloxifene InterMediate
Estrogen receptor modulator 1
BTC (Estrogen receptor modulator 1)
2-(4-Hydroxyphenyl)benzothiophene-6-ol
2-(4-Hydroxyphenyl)benzo[b]thiophen-6-ol
2-(4-hydroxyphenyl)-1-benzothiophen-6-ol
2-(4-hydroxyphenyl)-1-benzothiophene-6-ol
2-(4-Hydroxyphenyl)benzo[b]thiophene-6-ol
Benzo[b]thiophene-6-ol, 2-(4-hydroxyphenyl)-
所屬類別
醫(yī)藥中間體：噻吩類化合物物理化學(xué)性質(zhì)
熔點(diǎn)295 °C(dec.)
沸點(diǎn)477.0±30.0 °C(Predicted)
密度1.383
儲(chǔ)存條件Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
溶解度可溶于DMSO（少許）、甲醇（少許）
酸度系數(shù)(pKa)9.32±0.15(Predicted)
形態(tài)固體
顏色淺灰色
常見問題列表
生物活性
Estrogen receptor modulator 1 (compound 18) 是一種口服活性的選擇性 estrogen receptor 調(diào)節(jié)劑(SERM)，pIC50值為0.46。Estrogen receptor modulator 1具有潛在的抗腫瘤活性。靶點(diǎn)
| Target | Value |
|
ER
(Cell-free assay) | 0.46(pIC50) |
體外研究
Estrogen receptor modulator 1 (compound 18) (100 nM; 10 days) inhibits T47D:A18/PKCα and T47D:A18-TAM1 colony formation.
Estrogen receptor modulator 1 (100 nM; 9 days) significantly inhibits the growth of MCF-7:5C cell, and induces apoptosis in these cells 6 days.
Cell Proliferation Assay
| Cell Line: | T47D:A18/PKCα and T47D:A18-TAM1 cells |
| Concentration: | 100 nM |
| Incubation Time: | 10 days |
| Result: | Inhibit T47D:A18/PKCα and T47D:A18-TAM1 colony formation. |
Cell Viability Assay
| Cell Line: | MCF-7:5C cells |
| Concentration: | 100 nM |
| Incubation Time: | 9 days |
| Result: | Significantly inhibited the growth of MCF-7:5C cells. |
體內(nèi)研究
Estrogen receptor modulator 1 (1.5 mg/animal; p.o. ; daily for 2 weeks) results in regression of T47D:A18/PKCα tumors.
| Animal Model: | 4-6 week old athymic mice (Harlan-Sprague-Dawley) |
| Dosage: | 1.5 mg/animal |
| Administration: | p.o. ; daily for 2 weeks |
| Result: | Significantly reduced tumor volume. |