62232-46-6
62232-46-6 結(jié)構(gòu)式
基本信息
4-(2-芐基苯氧基)-N-甲基丁-1-胺鹽酸鹽
化合物BIFEMELANE HYDROCHLORIDE
Bifemelan hydrochloride
Bifemelane hydrochloride
MEAHDXWXNNDSAK-UHFFFAOYSA-N
4-(2-Benzylphenoxy)-N-methylbutan-1-amine hydrochloride
inhibit,Inhibitor,Monoamine Oxidase,MAO-A,MAO,MCI 2016,Bifemelane hydrochloride,antidepressant,Bifemelane,monoamine,MCI-2016,MCI2016,oxidase,MAO-B
物理化學(xué)性質(zhì)
常見(jiàn)問(wèn)題列表
|
MAO-A 4.2 μM (Ki) |
MAO-B 46 μM (Ki) |
Bifemelane inhibits MAO-A in a dose-dependent manner, with K
i
s of 4.2±0.2 and 14.1±0.7 μM in human brain synaptosomes and human liver mitochondria respectively.
Bifemelane inhibits MAO-B activities in a dose-dependent manner, with K
i
s of 46.0±3.6 and 65.2±7.0 μM in human brain synaptosomes and human liver mitochondria respectively.
Bifemelane (20-80 mg/kg; i.p.) dose-dependently decreases exploratory activity in the open field test.
Bifemelane (20-80 mg/kg; i.p.) decreases immobility time in the forced swim test, although is not clearly dosedependent and has already reached ceiling at 20 mg/kg.
| Animal Model: | Wistar male rats (230-270 g) are induced hypothermia by Reserpine |
| Dosage: | 20, 40, 80 mg/kg |
| Administration: | A single i.p. |
| Result: | Attenuated the Reserpine-induced hypothermia by a maximum of 10 ℃. |