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615253-61-7

中文名稱 615253-61-7
英文名稱 SP187
CAS 615253-61-7
分子式 C16H33NO5
分子量 319.44
MOL 文件 615253-61-7.mol
更新日期 2024/04/08 11:57:26
615253-61-7 結(jié)構(gòu)式 615253-61-7 結(jié)構(gòu)式

基本信息

中文別名
化合物 T16914
英文別名
UV4)
SP187
SP187 (MON-?DNJ
3,4,5-Piperidinetriol, 2-(hydroxymethyl)-1-(9-methoxynonyl)-, (2R,3R,4R,5S)-

物理化學(xué)性質(zhì)

沸點475.0±40.0 °C(Predicted)
密度1.128±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)13.72±0.70(Predicted)
形態(tài)Solid
顏色White to off-white

常見問題列表

生物活性
SP187 是一種靶向作用于宿主的針對絲狀病毒感染的亞胺糖。SP187 在體內(nèi)抗流感和登革熱。
靶點

IC50: 29.97 μM (EBOV), 47.72 μM (MARV)

體外研究

The antiviral activity of iminosugar SP187 (UV-4) in vitro against EBOV and MARV is assessed using a yield-plaque assay format and the IC 50 is determined. Antiviral activity for SP187 is observed with IC 50 of 29.97 and 47.72 μM for EBOV and MARV, respectively.

體內(nèi)研究

The efficacy of SP187 (UV-4), the active free base component of UV-4B, and UV-5, the most potent iminosugar tested in vitro, is first assessed using a mouse model of EBOV infection. In this study, C57Bl/6 mice are administered 10 or 100 mg/kg of SP187 or UV-5 via oral gavage or IP injection. Dosing started ~1h before infection with ~1000 pfu of mouse-adapted EBOV and is repeated BID for 10 days at approximately 12 hour intervals for UV-5 or TID at approximately 8 hour intervals for SP187. The selected doses and schedule are based on tolerability studies in na?ve mice. No efficacy is observed in the iminosugar treated mice as compared to the vehicle control.

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