61220-69-7
61220-69-7 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
沸點(diǎn)541.3±50.0 °C(Predicted)
密度1.372±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)4.14±0.10(Predicted)
形態(tài)Solid
顏色White to off-white
常見(jiàn)問(wèn)題列表
溶解度
體外：在DMSO中10mM 。
用途
硫平酸是一種二苯并噻吩，是具有口服活性且高度有效的抗炎，鎮(zhèn)痛和解熱劑。
體內(nèi)研究
Tiopinac (0.03-110 mg/kg) has 40 times the antiphlogistic potency of phenylbutazone. The dose required to reduce paw swelling by 30% is approximately 0.5 mg/kg. Tiopinac does not elicit overt side effects at the 20 mg/kg/day dose. Tiopinac causes a dose-related reversal of the decreases body weight caused by the adjuvant disease, the weight of those rats receiving 0.135 and 0.4 mg/kg/day being significantly greater than that of the positive controls. Tiopinac (0.3-30 mg/kg) is highly potent in inhibiting the pain evoked in the yeastinflamed hind paw of the rat.