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607736-84-5

中文名稱 607736-84-5
英文名稱 SUN 1334H
CAS 607736-84-5
分子式 C23H27ClF2N2O3
分子量 452.93
MOL 文件 607736-84-5.mol
607736-84-5 結(jié)構(gòu)式 607736-84-5 結(jié)構(gòu)式

基本信息

中文別名
化合物 T13040
英文別名
SUN 1334H

物理化學(xué)性質(zhì)

儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
形態(tài)Solid
顏色Light yellow to yellow
607736-84-5價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/11/08HY-U00084607736-84-5
SUN 1334H
607736-84-51mg1000元

常見問題列表

生物活性
SUN 1334H 是一種有效的,可口服的,選擇性的 H1 receptor 拮抗劑,Ki 值為 9.7 nM。
靶點(diǎn)

Ki: 9.7 nM (H1 receptor)

體外研究

SUN-1334H causes potent inhibition of histamine induced contractions of isolated guinea-pig ileum with an IC 50 (half the maximal inhibitory concentration) of 0.198 μM. In CHO-K1/hERG cells, SUN-1334H does not modulate hERG K + -currents at concentrations as high as 100 μM. SUN-1334H, cetirizine and hydroxyzine cause comparable inhibition of NLF leukocytes, IL-4 and total protein concentrations.

體內(nèi)研究

SUN-1334H potently inhibits histamine-induced bronchospasm over 24 hours following oral administration and completely suppresses histamine-induced skin wheal in beagle dogs and ovalbumin-induced rhinitis in guinea pigs. In skin allergy models, SUN-1334H shows potent reduction of passive and active cutaneous anaphylactic reactions. In central nervous system side effects models, SUN-1334H, desloratadine and fexofenadine are devoid of any significant effects.

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