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5874-97-5

中文名稱 硫酸奧西那林
英文名稱 Orciprenaline sulfate
CAS 5874-97-5
分子式 C22H36N2O10S
分子量 520.59
MOL 文件 5874-97-5.mol
更新日期 2025/03/21 10:44:06
5874-97-5 結(jié)構(gòu)式 5874-97-5 結(jié)構(gòu)式

基本信息

中文別名
硫酸異丙喘寧
硫酸奧西那林
硫酸奧昔帕林
異丙喘寧硫酸鹽
奧西那林硫酸鹽
硫酸奧腎上腺素
奧西那林半硫酸鹽
硫酸奧西那林 標(biāo)準(zhǔn)品
硫酸奧西那林(異丙喘寧)
奧西那林半硫酸鹽 標(biāo)準(zhǔn)品
英文別名
alotec
th-152
alupent
metaprel
Astmopent
novasmasol
ORCIPRENALINE SULFATE
METAPROTERENOL SULFATE
dl-Orciprenaline sulfate
METAPROTERENOLSULFATE,USP
所屬類別
原料藥:平喘藥

物理化學(xué)性質(zhì)

熔點(diǎn)202-203°
儲(chǔ)存條件2-8°C
溶解度Freely soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.
形態(tài)neat
顏色白色至灰白色
穩(wěn)定性吸濕性

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H332
危險(xiǎn)品標(biāo)志Xn
危險(xiǎn)類別碼20
安全說明36
WGK Germany2
RTECS號(hào)DO2275000
海關(guān)編碼2922504500
毒性LD50 in rats (mg/kg): 42 orally (Goldenthal)
硫酸奧西那林價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2025/02/08HY-B1276硫酸奧西那林
Metaproterenol hemisulfate
5874-97-55 mg171元
2025/02/08HY-B1276硫酸奧西那林
Metaproterenol hemisulfate
5874-97-510mM * 1mLin DMSO188元
2025/02/08HY-B1276硫酸奧西那林
Metaproterenol hemisulfate
5874-97-510 mg233元

常見問題列表

生物活性
Metaproterenol hemisulfate (Orciprenaline hemisulfate) 是一種直接作用的擬交感神經(jīng)藥,是 β2-腎上腺素能受體 (β2AR) 激動(dòng)劑,其 IC50 為 68 nM。Metaproterenol hemisulfate 還具有抗炎活性。
靶點(diǎn)

IC50: 68 nM (β2-adrenergic receptor)

體外研究

Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment enhances β-arrestin2 and its interaction with IκBα in high glucose-induced THP-1 cells and bone marrow macrophages.
Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment leads to downregulation of NF-κB in high glucose-induced THP-1 cells and bone marrow macrophages.

Western Blot Analysis

Cell Line: THP-1 cells and bone marrow macrophages
Concentration: 10 μM
Incubation Time: 74 hours
Result: Enhanced β-arrestin2 and its interaction with IκBα.

RT-PCR

Cell Line: THP-1 cells and bone marrow macrophages
Concentration: 10 μM
Incubation Time: 74 hours
Result: Led to downregulation of NF-κB.
體內(nèi)研究

Treatment of Zucker diabetic fatty rats with Metaproterenol for 12 weeks attenuates monocyte activation as well as pro-inflammatory and pro-fibrotic responses in the kidneys and heart. Thus, Metaproterenol might has protective effects against diabetic renal and cardiovascular complications.

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