58569-55-4
中文名稱(chēng)
[MET5]腦啡肽
英文名稱(chēng)
H-TYR-GLY-GLY-PHE-MET-OH
CAS
58569-55-4
分子式
C27H35N5O7S
分子量
573.66
MOL 文件
58569-55-4.mol
更新日期
2024/12/23 10:30:27
58569-55-4 結(jié)構(gòu)式
基本信息
中文別名
蛋氨酸腦啡肽蛋氨酸-腦啡呔
甲硫氨酸腦啡肽
[MET5]腦啡肽
酪氨酰甘氨酰-甘氨酰-苯丙氨酰-蛋氨酸
蛋氨酸腦啡肽|MET-ENKEPHALIN |[MET5]腦啡肽
英文別名
YGGFMlupex
ENKEPHALIN M
MET-ENKEPHALIN
Met-Enkephalie
ENDORPHIN (1-5)
5Met-enkephalin
Met-Enkephaline
ENKEPHALIN, MET-
[MET5]-ENKEPHALIN
所屬類(lèi)別
生物化工：多肽物理化學(xué)性質(zhì)
外觀性狀白色或類(lèi)白色粉末，由5個(gè)氨基酸組成，順序?yàn)長(zhǎng)-酪氨酸、甘氨酸、L-苯丙氨酸、L-甲硫氨酸。
熔點(diǎn)174-177 °C
比旋光度+31.5°(D/25℃)(c=0.96,メタノール)
沸點(diǎn)1052.9±65.0 °C(Predicted)
密度1.324±0.06 g/cm3(Predicted)
儲(chǔ)存條件−20°C
溶解度DMSO (Slightly), Methanol (Slightly, Heated, Sonicated), Water (Slightly)
酸度系數(shù)(pKa)3.23±0.10(Predicted)
形態(tài)powder
顏色white
序列H-Tyr-Gly-Gly-Phe-Met-OH
穩(wěn)定性Unstable in alkaline solution
制備方法
方法1
以L-酪氨酸、甘氨酸、L-苯丙氨酸、L-甲硫氨酸為原料，先將氨基酸中有側(cè)鏈的氨基酸的側(cè)鏈按其特性分別用保護(hù)劑保護(hù)后，在多肽縮合劑存在下進(jìn)行縮合反應(yīng)，然后除去保護(hù)劑純化制得。常見(jiàn)問(wèn)題列表
生物活性
Tyr-Gly-Gly-Phe-Met-OH 通過(guò)結(jié)合阿片樣物質(zhì)受體 (opioid receptor)，可調(diào)控人類(lèi)免疫功能，抑制腫瘤生長(zhǎng)。靶點(diǎn)
Opioid Receptor.
體外研究
Methionine enkephalin (MENK), an endogenous neuropeptide has a crucial role in both neuroendocrine and immune systems. MENK is believed to have an immunoregulatory activity to have cancer biotherapy activity by binding to the opioid receptors on immune and cancer cells. MENK may also change the tumor microenvironment by binding to opioid receptor on or in cancer cells. All of these mechanisms of action have biologic significance and potential for use in cancer immunotherapy. Furthermore, they reveal a relationship between the endocrine and immune systems.