5853-29-2
中文名稱(chēng)
鹽酸吐根酚堿
英文名稱(chēng)
cephaeline hydrochloride
CAS
5853-29-2
分子式
C28H39ClN2O4
分子量
503.08
MOL 文件
5853-29-2.mol
更新日期
2024/12/20 18:42:34
5853-29-2 結(jié)構(gòu)式
基本信息
中文別名
吐根酚堿鹽酸鹽 EP標(biāo)準(zhǔn)品 英文別名
NSC 32944Cephaeline DiHCl
Cephaeline HCl salt
cephaelin hydrochloride
Cephaeline dihydrochloride
Cephaeline dihydrochloroide
Cephaeline hydrochloride CRS
(-)-CEPHAELINE DIHYDROCHLORIDE
(1R)-1-[[(2S,3R,11bS)-3-Ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2H-benzo[a]quinolizin-2-yl]methyl]-1,2,3,4-tetrahydro-7-methoxy-6-isoquinolinol hydrochloride
所屬類(lèi)別
分析化學(xué)：藥典標(biāo)準(zhǔn)品和雜質(zhì)標(biāo)準(zhǔn)品物理化學(xué)性質(zhì)
外觀(guān)性狀類(lèi)白至黃色粉末，可溶于甲醇、乙醇、DMSO等有機(jī)溶劑，來(lái)源于吐根，安哥拉八角楓。
儲(chǔ)存條件4°C, protect from light
溶解度溶于二甲基亞砜
形態(tài)neat
顏色White to off-white
安全數(shù)據(jù)
警示詞危險(xiǎn)
危險(xiǎn)性描述H301
防范說(shuō)明P301+P310+P330
危險(xiǎn)品運(yùn)輸編號(hào)1544
危險(xiǎn)等級(jí)6.1(b)
包裝類(lèi)別III
毒性LD50 oral in mouse: 74970ug/kg
鹽酸吐根酚堿價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-N2260 | 鹽酸吐根酚堿 Cephaeline dihydrochloride | 5853-29-2 | 5mg | 1200元 |
| 2024/11/08 | HY-N2260 | 鹽酸吐根酚堿 Cephaeline dihydrochloride | 5853-29-2 | 10 mg | 1800元 |
| 2024/11/08 | HY-N2260 | 鹽酸吐根酚堿 Cephaeline dihydrochloride | 5853-29-2 | 25 mg | 3600元 |
常見(jiàn)問(wèn)題列表
生物活性
Cephaeline dihydrochloride 是選擇性的 CYP2D6 抑制劑，IC50 為 121 μM。靶點(diǎn)
IC50: 121 μM (CYP2D6)
Ki: 54 μM (CYP2D6)
體外研究
CYP2D6 reveals the highest metabolic activity for the generation of 9-O-demethylEmetine, whereas this enzyme also shows a significant metabolic activity for the generation of Cephaeline. The IC 50 s of Cephaeline against CYP2C9, CYP2D6 and CYP3A4 is over 1000, 121 and 1000 μM, respectively. Further experiments are performed to determine inhibition constants (K i ) for Cephaeline on the CYP2D6 and CYP3A4 activities Graphic analysis of Dixon plots at various Cephaeline concentrations for each of the two CYP enzyme assays yield K i s of 54 and 355 μM for CYP2D6 and CYP3A4, respectively.