568588-77-2
中文名稱
Hemopressin (rat)
英文名稱
Hemopressin (rat)
CAS
568588-77-2
分子式
C53H77N13O12
分子量
1088.26
MOL 文件
568588-77-2.mol
568588-77-2 結(jié)構(gòu)式
基本信息
中文別名
血紅蛋白 Α1 鏈HEMOPRESSIN(RAT) 英文別名
Hemopressin (rat)Hemopressin from rat
Hemopressin from rat brain
HeMopressin trifluoroacetate salt
Pro-Val-Asn-Phe-Lys-Phe-Leu-Ser-His trifluoroacetate salt
L-Histidine, L-prolyl-L-valyl-L-asparaginyl-L-phenylalanyl-L-lysyl-L-phenylalanyl-L-leucyl-L-seryl-
L-Prolyl-L-valyl-L-asparaginyl-L-phenylalanyl-L-lysyl-L-phenylalanyl-L-leucyl-L-seryl-L-histidine trifluoroacetate salt
物理化學(xué)性質(zhì)
儲(chǔ)存條件Desiccate at -20°C
溶解度H2O：≥2mg/mL
形態(tài)粉末
顏色白色至灰白色
序列H-Pro-Val-Asn-Phe-Lys-Phe-Leu-Ser-His-OH
常見問題列表
生物活性
Hemopressin(rat) 是一種源自血紅蛋白 α1 鏈的九肽，最初是從大鼠腦勻漿中分離出來的。Hemopressin(rat) 是口服有效的，選擇性的 CB1 大麻素受體的反向激動(dòng)劑。Hemopressin(rat) 在炎性疼痛模型中發(fā)揮抗傷害感受作用。體內(nèi)研究
Hemopressin(rat) causes hypotension in anesthetized rats and is metabolized in vivo and in vitro by endopeptidase 24.15 (EP24.15), neurolysin (EP24.16), and angiotensin-converting enzyme (ACE).
Oral administration of Hemopressin(rat) inhibits mechanical hyperalgesia of CCI-rats up to 6h. Hemopressin(rat) treatment also decreases Egr-1 immunoreactivity (Egr-1Ir) in the superficial layer of the dorsal horn of the spinal cord of CCI rats.