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568544-03-6

中文名稱 568544-03-6
英文名稱 2-CHLORO-N-(4-CHLORO-3-DIMETHYLSULFAMOYL-PHENYL)-ACETAMIDE
CAS 568544-03-6
分子式 C10H12Cl2N2O3S
分子量 311.18
MOL 文件 568544-03-6.mol
更新日期 2025/02/19 11:56:28
568544-03-6 結(jié)構(gòu)式 568544-03-6 結(jié)構(gòu)式

基本信息

中文別名
化合物GSTO1-IN-1
2-氯-N-(4-氯-3-(N,N-二甲基氨磺酰)苯基)乙酰胺
英文別名
GSTO1-IN-1
GSTO1 inhibitor 1
2-CHLORO-N-(4-CHLORO-3-DIMETHYLSULFAMOYL-PHENYL)-ACETAMIDE
Acetamide, 2-chloro-N-[4-chloro-3-[(dimethylamino)sulfonyl]phenyl]-

物理化學(xué)性質(zhì)

儲存條件Keep in dark place,Inert atmosphere,2-8°C
形態(tài)Solid
顏色Light yellow to yellow
568544-03-6價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2025/02/08HY-111530GSTO1-IN-1568544-03-65 mg937元
2025/02/08HY-111530568544-03-6
GSTO1-IN-1
568544-03-610mg1500元
2025/02/08HY-111530568544-03-6
GSTO1-IN-1
568544-03-610mM * 1mLin DMSO1650元

常見問題列表

生物活性
GSTO1-IN-1 是一種有效的谷胱甘肽 S-轉(zhuǎn)移酶 omega 1 (GSTO1) 抑制劑,IC50 為 31 nM。
靶點

IC50: 31 nM (GSTO1)

體外研究

GSTO1-IN-1 (C1-27) potently inhibits GSTO1 enzyme activity with an IC 50 value of 31 nM. GSTO1-IN-1 also potently competes with 5-chloromethylfluorescein diacetate (CMFDA) for binding to recombinant protein, as well as endogenous GSTO1 in the milieu of a soluble proteome. HCT116 cells treated with GSTO1-IN-1 also show a decrease in cell viability in a dose-dependent manner. GSTO1-IN-1 inhibits the clonogenic survival of HCT116 cells at sub-micromolar concentrations.

體內(nèi)研究

To test whether GSTO1-IN-1 had in vivo efficacy, its effects are evaluated in a human colon cancer cell line xenograft model. GSTO1-IN-1 (20-45 mg/kg) is administered as a single agent to nude mice bearing HCT116 xenografts. After 5 weeks of treatment, tumor growth is significantly inhibited in GSTO1-IN-1-treated mice compared with the vehicle-treated group (P<0.05). GSTO1-IN-1 treatment is generally well tolerated by mice up to 45 mg/kg, with no overt signs of toxicity and no significant variations in average body weights throughout the duration of the study.

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