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56488-59-6

中文名稱 特丁貝羅
英文名稱 Terbufibrol
CAS 56488-59-6
分子式 C20H24O5
分子量 344.4
MOL 文件 56488-59-6.mol
56488-59-6 結(jié)構(gòu)式 56488-59-6 結(jié)構(gòu)式

基本信息

中文別名
特丁貝羅
英文別名
K-11267
Terbufibrol
Reaxys ID: 2949416
p-[3-(p-tert-Butylphenoxy)-2-hydroxypropoxy]benzoic acid
p-[[3-(p-t-Butylphenoxy)-2-hydroxypropyl]oxy]benzoic acid
Benzoic acid, 4-[3-[4-(1,1-dimethylethyl)phenoxy]-2-hydroxypropoxy]-

物理化學(xué)性質(zhì)

沸點439.5°C (rough estimate)
密度1.1444 (rough estimate)
折射率1.5400 (estimate)
儲存條件-20°C儲存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)4.41±0.10(Predicted)

常見問題列表

生物活性
Terbufibrol 在正常和高膽固醇血癥雄性大鼠中,高效降低血清總膽固醇 (TC) 水平。
體內(nèi)研究

Terbufibrol (20-200 mg/kg) is active in lowering serum TC in animals on all 3 diets, but the extent of cholesterol reduction varies in the order cholesterol (HC)>high protein and fat diet (HPF)>N (max. reductions: 154, 80, and 70%, respectively). Clofibrate (200 mg/kg) decreases TC by a maximum of 28% with the HPF-diet and 13% with the N-diet but is inactive with the HC-diet. Cholestyramine (400 mg/kg/day) is inactive in HPF-fed animals but reduces TC in HC-fed animals by 45%. With the HPF-diet nicotinic acid (200 mg/kg) is inactive. Terbufibrol lowers HDL, HDL-TC, LDL, LDL-TC and LDL-TC/PL in animals fed HPF-diet. A greater decrease of LDL-TC occurres with increasing dose. The main effect of Clofibrate (200 mg/kg) is to reduce HDL and HDL-TC and to increase LDL.

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