5610-40-2
基本信息
一葉堿
葉底珠堿
一葉萩堿
一葉秋堿
硝酸一葉秋堿
一葉萩堿、一葉秋堿
一葉秋堿 ,一葉萩堿
SECURININE 一葉萩堿
一葉秋堿 ,一葉萩堿(標(biāo)準(zhǔn)品)
SECURININE
Securan one
(-)-securinin
SECURAN-11-ONE
SECURININE(RG)
Securinan-11-on
securinan-11-one
(2β,7S,9S)-Securinan-11-one
1,2,3,4,10,10a-Hexahydro-10-hydroxy-
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
常見問題列表
Target | Value |
GABA receptor
() |
(-)-Securinine is a major plant-derived alkaloid and also a GABA A receptor antagonist. (-)-Securinine is significantly potent on HeLa cells growth inhibition with IC 50 values of 7.02±0.52 μg/mL (32.3 μM). (-)-Securinine induces apoptosis in a dose-dependent manner in the tested cells, increases the percentage of ROS positive cells and depolarized cells as well as stimulates the activity of ERK1/2, caspase-9 and -3/7. (-)-Securinine also induces cell cycle arrest in S phase. Real-time PCR analysis shows high expression of tumor necrosis factor receptor superfamily (TNFRSF) genes in the cells stimulated with (-)-Securinine.
In this tumor model, tumor growth is significantly impaired with (-)-Securinine treatment indicating that (-)-Securinine has potential as an Acute Myeloid Leukemia (AML) therapeutic. (-)-Securinine treated mice (n=5 mice, bilateral tumors), exhibit an average of more than 75% smaller tumors than vehicle treated mice at the end of the study period.