55476-47-6
中文名稱
10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine
英文名稱
10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine
CAS
55476-47-6
分子式
C19H15NO3S
分子量
337.39
MOL 文件
55476-47-6.mol
55476-47-6 結構式
基本信息
中文別名
化合物PSB-12062 英文別名
PSB-12062PSB-12062 >=98% (HPLC)
10-Tosyl-10H-phenoxazine
N-(p-Methylphenylsulfonyl)phenoxazine
10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine
10H-Phenoxazine, 10-[(4-methylphenyl)sulfonyl]-
10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine價格(試劑級)
| 報價日期 | 產品編號 | 產品名稱 | CAS號 | 包裝 | 價格 |
| 2024/11/08 | HY-101910 | 10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine PSB-12062 | 55476-47-6 | 5mg | 600元 |
| 2024/11/08 | HY-101910 | 10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine PSB-12062 | 55476-47-6 | 10mM * 1mLin DMSO | 660元 |
| 2024/11/08 | HY-101910 | 10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine PSB-12062 | 55476-47-6 | 10mg | 900元 |
常見問題列表
生物活性
PSB-12062是有效，選擇性的 P2X4 拮抗劑，對人類 P2X4 的 IC50 值為1.38 μM。靶點
IC50: 1.38 μM (human P2X4), 92.8 nM (rat P2X4), 1.76 μM (mouse P2X4)
體外研究
PSB-12062 shows similar potency in human, rat, and mouse species. PSB-12062 shows to be allosteric in nature with a 35-fold selectivity toward P2X4 versus P2X1, P2X2, P2X3, and P2X7. However, PSB-12062 is unable to completely block ATP-induced P2X4-mediated calcium influx even when used at high concentrations (>30 μM).