552332-71-5
CAS
552332-71-5
常見問(wèn)題列表
生物活性
DB07107 是一種有效的抗藥性 T315I 突變 Bcr-Abl (T315I mutant Bcr-Abl) 酪氨酸激酶抑制劑。DB07107 還是一種有效的 Akt1 抑制劑，IC50 值為 360 nM。靶點(diǎn)
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Akt1 360 nM (IC 50 ) |
體外研究
DB07107 is more effective in blocking drug-resistant T315I mutant than the wild-type Bcr-Abl. DB07107 (C23H22N4O) from DrugBank showed the highest binding energy with XP score of -14.045 kcal/mol.