546-78-1
中文名稱
[1R,5S,(-)]-4-Methyl-1-isopropylbicyclo[3.1.0]hexa-3-ene-2-one
英文名稱
[1R,5S,(-)]-4-Methyl-1-isopropylbicyclo[3.1.0]hexa-3-ene-2-one
CAS
546-78-1
MOL 文件
546-78-1.mol
546-78-1 結(jié)構(gòu)式
基本信息
英文別名
ThujenoneThujen-2-one
(-)-Umbellulone
(1R,5S)-(-)-3-Thujen-2-one
(-)-Umbellulone >=98% (HPLC)
(1R, 5S)-4-Methyl-1-propan-2-ylbicyclo(3.1.0)hex-3-en-2-one
[1R,5S,(-)]-4-Methyl-1-isopropylbicyclo[3.1.0]hexa-3-ene-2-one
所屬類別
醫(yī)藥中間體：原料藥中間體物理化學(xué)性質(zhì)
儲(chǔ)存條件-20°C
溶解度DMSO : 250 mg/mL (1664.23 mM; Need ultrasonic)
形態(tài)Oil
顏色無(wú)色至淺棕色
常見(jiàn)問(wèn)題列表
生物活性
Umbellulone 是 Umbellularia californica 葉中的一種活性成分。在肽能、傷害感受神經(jīng)元亞群中，Umbellulone 刺激 TRPA1通道，并通過(guò)這一機(jī)制激活三叉神經(jīng)血管系統(tǒng)。靶點(diǎn)
TRPA1 channel
體外研究
Umbellulone, from μM to sub-mM concentrations, selectively stimulates transient receptor potential ankyrin 1-expressing HEK293 cells.
體內(nèi)研究
Umbellulone (50–250?nM/5ul) causes an acute nocioceptive response in a dose-dependent manner in Trpa1
+/+
mice.
Umbellulone (150?μg/kg; intravenous or intranasal) do not affect systemic blood pressure.
Umbellulone (30-150 μg/kg; i.v.) increases meningeal blood flow in a dose-dependent manner.
| Animal Model: | Sprague-Dawley rats (male, 250?g) |
| Dosage: | 30 μg/kg, 75 μg/kg, 150 μg/kg |
| Administration: | Intravenously |
| Result: | Increased meningeal blood flow in a dose-dependent manner. |