52811-37-7
中文名稱
2,5-二羥基-4-甲氧基二苯甲酮
英文名稱
Cearoin
CAS
52811-37-7
分子式
C14H12O4
分子量
244.24
MOL 文件
52811-37-7.mol
更新日期
2023/03/20 15:41:17
52811-37-7 結構式
基本信息
中文別名
2,5-二羥基-4-甲氧基二苯甲酮 英文別名
Cearoin(2,5-dihydroxy-4-methoxyphenyl)phenylmethanone
Phenyl(2,5-dihydroxy-4-methoxyphenyl)methanone
Methanone, (2,5-dihydroxy-4-methoxyphenyl)phenyl-
物理化學性質
熔點188 °C(Solv: ethanol (64-17-5))
沸點443.8±45.0 °C(Predicted)
密度1.296±0.06 g/cm3(Predicted)
儲存條件4°C, protect from light
酸度系數(shù)(pKa)8.25±0.48(Predicted)
形態(tài)Solid
顏色Light yellow to green yellow
2,5-二羥基-4-甲氧基二苯甲酮價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2025/02/08 | HY-N8418 | 2,5-二羥基-4-甲氧基二苯甲酮 Cearoin | 52811-37-7 | 1mg | 2500元 |
常見問題列表
生物活性
Cearoin 可從Dalbergia odorifera中分離，通過促進 ROS 產(chǎn)生和激活 ERK 來增強自噬 (autophagy) 和誘導細胞凋亡(apoptosis)。靶點
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ERK
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ROS
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Autophagy
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Apoptosis
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體外研究
Cearoin (10-80 μM) induces cell death in a dose-dependent manner.
Cearoin (10-80 μM) increases the phosporylation of ERK in SH-SY5Y cells.
Cearoin (5-80 μM) increases the conversion of LC3B-I to LC3B-II in SH-SY5Y cells. The expression of LC3B-II is a good marker for autophagosome formation in the autophagy process.
Cell Viability Assay
| Cell Line: | Human neuroblastoma SH-SY5Y cells |
| Concentration: | 0, 1, 5, 10, 20, 40, or 80 μM |
| Incubation Time: | 6 or 12 hours |
| Result: | Significantly decreased cell viability from 10 μM in a dose-dependent manner. Treatment with 40 μM for 12 h induced about 50% loss in cell viability in SH-SY5Y cells. |
Western Blot Analysis
| Cell Line: | Human neuroblastoma SH-SY5Y cells |
| Concentration: | 0, 5, 10, 20, 40, or 80 μM |
| Incubation Time: | 12 hours |
| Result: |
Increased ERK phosphorylation in a dose-dependent manner, whereas it did not alter JNK phosphorylation.
Induced the formation of LC3B-II in a dose dependent manner. |