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516-35-8

中文名稱 ?;蛆Z去氧膽酸
英文名稱 Taurochenodeoxycholic acid
CAS 516-35-8
分子式 C26H45NO6S
分子量 499.7
MOL 文件 516-35-8.mol
更新日期 2024/12/25 10:15:42
516-35-8 結(jié)構(gòu)式 516-35-8 結(jié)構(gòu)式

基本信息

中文別名
?;蛆Z脫氧膽酸
牛磺鵝去氧膽酸
?;蛆Z去氧膽酸鈉鹽
純天然?;蛆Z去氧膽酸
牛磺鵝去氧膽酸標(biāo)準(zhǔn)品
?;蛆Z去氧膽酸對照品
?;蛆Z脫氧膽酸(TCDCA)
?;蛆Z去氧膽酸?, 99.5%
?;蛆Z脫氧膽酸(?;蛆Z去氧膽酸)
【純天然?;蛆Z去氧膽酸】醫(yī)藥含量98%白色粉末
英文別名
TCDCA
C05465
Chenyltaurine
12-Deoxycholyltaurine
Taurochenodeoxycholic
12-Desoxycholyltaurine
Chenodeoxycholyltaurine
aurochenodeoxycholicaci
Chenodeoxycholoyltaurine
Taurochenodeoxycholic acid
所屬類別
生物化工:提取物

物理化學(xué)性質(zhì)

外觀性狀白色結(jié)晶體,可溶于甲醇、乙醇、DMSO等有機(jī)溶劑,來源于動(dòng)物膽汁。
熔點(diǎn)186-200°C
密度1.216±0.06 g/cm3(Predicted)
儲(chǔ)存條件Sealed in dry,Room Temperature
溶解度可溶于氯仿、甲醇
酸度系數(shù)(pKa)1.42±0.50(Predicted)
形態(tài)固體
顏色白色至淺米色

應(yīng)用領(lǐng)域

用途1
用于含量測定/鑒定/藥理實(shí)驗(yàn)等。
?;蛆Z去氧膽酸價(jià)格(試劑級)
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/11/08HY-N2027?;蛆Z去氧膽酸
Taurochenodeoxycholic acid
516-35-825 mg400元
2024/11/08HY-N2027?;蛆Z去氧膽酸
Taurochenodeoxycholic acid
516-35-810mM * 1mLin DMSO440元
2024/11/08HY-N2027?;蛆Z去氧膽酸
Taurochenodeoxycholic acid
516-35-850mg600元

常見問題列表

生物活性
Taurochenodeoxycholic acid (12-Deoxycholyltaurine) 是動(dòng)物膽汁酸的主要生物活性物質(zhì)之一。Taurochenodeoxycholic acid 可誘導(dǎo)細(xì)胞凋亡 (apoptosis),并具有明顯的抗炎和免疫調(diào)節(jié)作用。
靶點(diǎn)

Human Endogenous Metabolite

體外研究

Taurochenodeoxycholic acid (12-Deoxycholyltaurine) dramatically improves the apoptosis rate of NR8383 cells in a concentration-dependent manner. In the meantime, Taurochenodeoxycholic acid significantly augments PKC mRNA levels, activities and increases JNK, caspase-3 and caspase-8 mRNA expression levels, activities.

體內(nèi)研究

Taurochenodeoxycholic acid (12-Deoxycholyltaurine; 0.05, 0.1g/kg) decreases the pulmonary coefficient in the model mice and reduces the pathological damages on their lungs; it can decrease the expression levels of TNF-α and TIMP-2 in pulmonary tissues in the pulmonary fibrosis mice and has no significant effects on MMP2.
Taurochenodeoxycholic acid significantly normalizes the clinical inflammatory parameters, prevented indomethacin-induced increases in the biliary contents of secondary bile acids and hydrophobicity index, and tended to attenuate the intestinal inflammation.
Taurochenodeoxycholic acid significantly suppresses paw swelling and polyarthritis index, increases the loss body weight and index of thymus and spleen, and amends radiologic changes in AA rats. The overproduction and mRNA expression of TNF-α, IL-1β and IL-6 are remarkably suppressed in serum and synovium tissue of all TCDCA-treated rats.

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