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5081-48-1

中文名稱 玫瑰樹堿鹽酸鹽
英文名稱 Ellipticine (hydrochloride)
CAS 5081-48-1
分子式 C17H15ClN2
分子量 282.77
MOL 文件 5081-48-1.mol
更新日期 2025/01/01 10:46:12
5081-48-1 結(jié)構(gòu)式 5081-48-1 結(jié)構(gòu)式

基本信息

中文別名
玫瑰樹鹽酸鹽
玫瑰樹堿鹽酸鹽
ELLIPTICINE 鹽酸鹽
英文別名
NSC 71795 (hydrochloride)
Ellipticine hydrochloride(NSC 71795 hydrochloride)
所屬類別
有機(jī)原料:羧酸類化合物及衍生物

物理化學(xué)性質(zhì)

儲存條件Inert atmosphere,Store in freezer, under -20°C
溶解度DMSO:4.4(Max Conc. mg/mL);15.56(Max Conc. mM)
形態(tài)結(jié)晶固體
顏色Light yellow to yellow

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險性描述H302-H315-H319-H335
玫瑰樹堿鹽酸鹽價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/11/08S6790玫瑰樹堿鹽酸鹽
Ellipticine hydrochloride
5081-48-15mg587.68元
2024/11/08S6790玫瑰樹堿鹽酸鹽
Ellipticine hydrochloride
5081-48-125mg1970元

常見問題列表

生物活性
Ellipticine Hydrochloride (NSC 71795, PZE)是一種有效的 DNA topoisomerase II 的抑制劑,并通過其與 cytochromes P450 (CYP) 和 peroxidases 的氧化作用介導(dǎo)形成共價DNA加合物。Ellipticine Hydrochloride 是從澳大利亞的夾竹桃科常綠喬木中分離出來的具有抗腫瘤活性的天然產(chǎn)物。
靶點
TargetValue
P450
()
peroxidase
()
Topo II
()
體外研究

Ellipticine (NSC 71795) is a potent antineoplastic agent exhibiting the multimodal mechanism of its action. The mechanisms of Ellipticine (NSC 71795) antitumor, mutagenic and cytotoxic activities are suggested to be intercalation into DNA and inhibition of DNA topoisomerase II activity. Another mode of Ellipticine (NSC 71795) action is the formation of covalent DNA adducts mediated by its oxidation with cytochromes P450 (CYP) and peroxidases. Ellipticine (NSC 71795) can also act as an inhibitor or inducer of biotransformation enzymes, thereby modulating its own metabolism leading to its genotoxic and pharmacological effects. Treatment of cells with Ellipticine (NSC 71795) results in inhibition of cell growth and proliferation. This effect is associated with formation of two covalent Ellipticine (NSC 71795)-derived DNA adducts.

體內(nèi)研究

Ellipticine (NSC 71795) treatment results in ellipticine-derived DNA adduct generation in several healthy organs (liver, kidney, lung, spleen, breast, heart and brain) and in DNA of mammary adenocarcinoma. The levels of Ellipticine (NSC 71795)-derived DNA adducts generated in these adenocarcinomas are almost 2-fold higher than in normal healthy mammary tissue. The induced expression of cytochrome b 5 protein in liver of rats treated with Ellipticine (NSC 71795) suggests that cytochrome b 5 may modulate the CYP-mediated bioactivation and detoxification of Ellipticine (NSC 71795).

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