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505-44-2

中文名稱 3-甲基亞磺酰丙基異硫氰酸酯
英文名稱 IBERIN
CAS 505-44-2
分子式 C5H9NOS2
分子量 163.26
MOL 文件 505-44-2.mol
505-44-2 結(jié)構(gòu)式 505-44-2 結(jié)構(gòu)式

基本信息

中文別名
化合物 T15544
3-甲基亞磺酰丙基異硫氰酸酯
英文別名
IBERIN
lberin
NSC 321801
IBERIN(RG)
3-methylsulphinylpropylisothiocyanate
3-(Methylsulfinyl)propyl isothiocyanate
Methyl(3-isothiocyanatopropyl) sulfoxide
3-methylsulfinylpropylimino(thioxo)methane
1-isothiocyanato-3-(methylsulfinyl)propane
1-ISOTHIOCYANATO-3-(METHYLSULPHINYL)-PROPANE
所屬類別
化學(xué)試劑:氰酸酯/異氰酸酯

物理化學(xué)性質(zhì)

沸點(diǎn)240.37°C (rough estimate)
密度1.142 (estimate)
折射率1.5237 (estimate)
儲存條件Hygroscopic, Refrigerator, under inert atmosphere
溶解度可溶于氯仿(少許)、甲醇(少許)
形態(tài)Oil
顏色無色
穩(wěn)定性濕氣敏感

常見問題列表

生物活性
Iberin (NSC 321801) 是蘿卜硫素的亞砜類似物,是天然存在的異硫氰酸酯家族的成員。抑制 HL60 細(xì)胞的 IC50 值為 2.3 μM。Iberin 誘導(dǎo)凋亡 (apoptosis)。
靶點(diǎn)

Human Endogenous Metabolite

體外研究

Iberin inhibits the growth of neuroblastoma cells in a dose- and time-dependent manner. The iberin-induced cell cycle arrest in neuroblastoma cells is associated with inhibition of expression of cyclin-dependent kinase Cdk2, Cdk4, and Cdk6 proteins. There is an increase in apoptotic cell death in iberin treated cells as compared with control cells. The iberin-induced apoptosis is found to be associated with activation of caspase-9, caspase-3, and PARP. Iberin inhibits growth of human glioblastoma cells in cell proliferation assays, enhances cytotoxicity, and induces apoptosis by activation of caspase-3 and caspase-9.

體內(nèi)研究

Iberin is tested in an in vivo foreign-body infection mouse model, and the results show no significantly difference in bacterial clearance between treated and nontreated miced. Iberin increases tissue levels of the phase II detoxification enzymes quinone reductase and glutathione S-transferase in a variety of rat tissues.

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