490-31-3
中文名稱
洋槐黃素
英文名稱
ROBINETIN
CAS
490-31-3
分子式
C15H10O7
分子量
302.24
MOL 文件
490-31-3.mol
更新日期
2024/12/19 21:18:23
490-31-3 結(jié)構(gòu)式
基本信息
中文別名
洋槐黃素洋槐黃素對(duì)照品
洋槐黃素標(biāo)準(zhǔn)品
英文別名
ROBINETINnorkanugin
5-HYDROXYFISETIN
5-HYDROXYFISETIN hplc
3,3’,4’,5’,7-pentahydroxy-flavon
3,7,3',4',5'-PENTAHYDROXYFLAVONE
3,7,3'',4'',5''-PENTAHYDROXYFLAVONE WITH HPLC
3,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-4-benzopyrone
3,7-Dihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chromen-4-one
3,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-4h-1-benzopyran-4-on
所屬類別
天然產(chǎn)物：黃酮類化合物物理化學(xué)性質(zhì)
熔點(diǎn)326-328°C
沸點(diǎn)363.28°C (rough estimate)
密度1.3616 (rough estimate)
折射率1.4790 (estimate)
儲(chǔ)存條件Sealed in dry,2-8°C
溶解度DMSO（微溶）、甲醇（微溶，加熱）
酸度系數(shù)(pKa)6.82±0.40(Predicted)
形態(tài)固體
顏色黃色至深黃色
LogP2.550 (est)
常見問題列表
生物活性
Robinetin (3,3',4',5',7-Pentahydroxyflavone) 是一種天然黃酮，具有顯著的“兩種顏色”固有熒光特性，具有抗真菌、抗病毒、抗菌、抗突變和抗氧化活性。Robinetin 還可以抑制脂質(zhì)過氧化和蛋白質(zhì)糖基化。體外研究
Robinetin (0.1-10 μM; 1 h) inhibits HIV integrase cleavage and integration in a dose-dependent manner.
Robinetin inhibits the DNA synthesis in
Proteus vulgaris
, and the RNA synthesis in S.
aureus
.
Robinetin (100-200 or 25 μM; 1 or 72 h) inhibits egg yolk phosphatidylcholine (EYPC) membrane lipid peroxidation and hemoglobin A (HbA) glycosylation with high efficiency.
Robinetin exhibits photo-induced excited-state intramolecular proton transfer resulting in ‘two color’ (in ‘blue-violet’ and ‘yellow-green’ regions) fluorescence characteristic of flavonols, the relative contributions between the two colors being strongly modulated by the local environment of the fluorophore.