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482-38-2

中文名稱 山奈苷
英文名稱 KAEMPFERITRIN
CAS 482-38-2
分子式 C27H30O14
分子量 578.52
MOL 文件 482-38-2.mol
更新日期 2025/01/07 15:49:20
482-38-2 結(jié)構(gòu)式 482-38-2 結(jié)構(gòu)式

基本信息

中文別名
山奈苷
山奈苷對(duì)照品,
7-二鼠李糖苷)
山奈苷(標(biāo)準(zhǔn)品)
山奈苷(山奈酚-3
山奈苷, 來源于萬壽菊
山奈酚-3,7-二鼠李糖苷
山奈酚-3,7-O-L-二鼠李糖苷
KAEMPFERITRIN 山奈苷
山奈苷(山奈酚-3,7-二鼠李糖苷)
英文別名
Lespedin
lespenefril
Lespenephryl
lespenephril
KAEMPFERITRIN(P)
Kaempferitrin (Lespedin
KaeMpferol3,7bisrhaMnoside
Kaempherol 3,7-bismannoside
KAEMPFEROL-3,7-DIRHAMNOSIDE
Kaempferol 3,7-L-dirhamnoside
所屬類別
天然產(chǎn)物:黃酮類化合物

物理化學(xué)性質(zhì)

外觀性狀黃色結(jié)晶,可溶于甲醇、乙醇、DMSO等有機(jī)溶劑,來源于雞冠花、傘形科植物柴胡,萬壽菊,山奈。
熔點(diǎn)202~203℃
沸點(diǎn)908.6±65.0 °C(Predicted)
密度1.70
儲(chǔ)存條件-20°C
溶解度DMSO : 125 mg/mL (216.07 mM; Need ultrasonic)
酸度系數(shù)(pKa)5.81±0.40(Predicted)
形態(tài)粉末
顏色白色至米色

安全數(shù)據(jù)

應(yīng)用領(lǐng)域

用途1
用于含量測(cè)定/鑒定/藥理實(shí)驗(yàn)等。
藥理藥效:具有降血糖和抗疲勞活性,清熱解毒、 消腫止痛。
用途2
山奈苷具有降血糖、抗疲勞、清熱解毒,消腫止痛的作用。

圖譜信息

山奈苷價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/11/08S9112山奈苷
Kaempferitrin
482-38-21mg1204.24元

常見問題列表

生物活性
Kaempferitrin 是一種天然黃酮苷類化合物,具有鎮(zhèn)痛、消炎、抗糖尿病、抗腫瘤和化療的作用,同時(shí)可激活胰島素 (insulin) 信號(hào)傳導(dǎo)。
靶點(diǎn)

Insulin Receptor

體外研究

Kaempferitrin activates insulin signaling pathway. Kaempferitrin causes survival rates higher than 90% at 1-20 μM in matured 3T3-L1 adipocyte, and the survival rates decline rapidly at 25 and 50 μM. Kaempferitrin (15 μM) increases insulin receptor beta tyrosine phosphorylation and tyrosine phosphorylation of the insulin receptor substrate 1, and such effects are similar to that of 10 nM insulin. Kaempferitrin (15 μM) also stimulates akt phosphorylation on ser473, and the stimulation can be blocked by a PI3-K inhibitor wortmannin. Kaempferitrin potently exerts the translocation of GLUT4 to the membrane of adipocytes at 15 μM, and this is suppressed by wortmannin. In addition, Kaempferitrin increases the total levels of Glu4 protein in differentiated cells and secreted adiponectin in mature 3T3-L1 adipocytes. Kaempferitrin is cytotoxic to human cancer cells such as HeLa and MDA-MB231 cells, with IC 50 s of 45 ± 2.6 and 65 ± 2.6 μM, and shows low toxic effects on non-tumorigenic cells. Kaempferitrin (45 μM) induces apoptosis of HeLa cells after treatment for 24 and 48 h, and causes reactive oxygen species (ROS) generation in HeLa cells. Furthermore, Kaempferitrin (45 μM) exerts G1 arrest, causes the expression of proteins associated with intrinsic pathway of apoptosis and activates caspase 3 in HeLa cells.

體內(nèi)研究

Kaempferitrin (2.5, 10 and 25 mg/kg, i.p.) markedly suppresses the growth of tumor by 40%, 87% and 97%, and decreases tumor weight by 37%, 81% and 95%, respectively in nu/nu mice bearing HeLa tumor. Kaempferitrin also inhibits cell proliferation and extends life span in mice bearing tumor.

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