440645-08-9
CAS
440645-08-9
分子式
C60H103N17O23
更新日期
2024/10/24 11:51:24
440645-08-9 結(jié)構(gòu)式
常見問題列表
生物活性
α-Synuclein (61-75) 是 α-Synuclein 的 61-75 片段。α-Synuclein 是一種豐富的神經(jīng)元蛋白,在突觸前神經(jīng)末梢高度豐富。α-Synuclein 是一種帕金森氏病 (PD) 的生物標(biāo)志物。體外研究
Lewy bodies containing α-Synuclein are a neuropathological hallmark of PD, and missense mutations in α-Synuclein (A30P, E46K, H50Q, G51D, A53E, A53T), as well as α-Synuclein gene duplications and triplications, appear to cause PD. Moreover, polymorphisms in regulatory elements of the α-Synuclein gene predispose individuals to PD and are linked to an early onset of the disease. The non-Aβ-amyloid component (NAC) region of α-synuclein is relatively hydrophobic and aggregation-prone in human α-Synuclein but not in mouse α-Synuclein nor in the corresponding homologous region of human β-synuclein. Yet, β-synuclein is more homologous to α-synuclein in the N-terminal sequences (74%) than γ-synuclein (67%).