439946-22-2
中文名稱
LDN-91946
英文名稱
3-amino-2-benzoyl-6-oxo-7H-thieno[2,3-b]pyridine-5-carboxylic acid
CAS
439946-22-2
分子式
C15H10N2O4S
分子量
314.32
MOL 文件
439946-22-2.mol
439946-22-2 結(jié)構(gòu)式
基本信息
中文別名
化合物 T15729化合物L(fēng)DN-91946
英文別名
3-amino-2-benzoyl-6-oxo-7H-thieno[2,3-b]pyridine-5-carboxylic acidThieno[2,3-b]pyridine-5-carboxylic acid, 3-amino-2-benzoyl-6,7-dihydro-6-oxo-
物理化學(xué)性質(zhì)
熔點(diǎn)327-329 °C(Solv: acetic acid (64-19-7))
沸點(diǎn)714.0±60.0 °C(Predicted)
密度1.554±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO: 83.33 mg/mL (265.11 mM)
酸度系數(shù)(pKa)2.26±0.20(Predicted)
形態(tài)Solid
顏色Light brown to brown
常見(jiàn)問(wèn)題列表
生物活性
LDN-91946 是一種有效的非競(jìng)爭(zhēng)性的選擇性泛素羧基末端水解酶-L1 (UCH-L1) 抑制劑，Ki app 為 2.8 μM.靶點(diǎn)
Ki app: 2.8 μM (UCH-L1)
體外研究
LDN-91946 is inactive against UCH-L3 at 20 μM. LDN-91946 demonstrates no activity against TGase 2, Papain, and Caspase-3 at 40 μM.
There is no cytotoxicity when serum-starved Neuro 2A (N2A) cells are treated with LDN-91946 at concentrations as high as 0.1 mM.