4303-67-7
中文名稱
1-十二烷基咪唑
英文名稱
1-DODECYLIMIDAZOLE
CAS
4303-67-7
分子式
C15H28N2
分子量
236.4
MOL 文件
4303-67-7.mol
更新日期
2024/12/24 08:55:20
4303-67-7 結(jié)構(gòu)式
基本信息
中文別名
1-十二咪唑N-十二烷基咪唑
1-十二烷基咪唑
N-正十二烷基咪唑
1-十二烷基咪唑 25G
(3R,4S)-1-芐基-N,4-二甲基哌啶-3-胺
英文別名
C12IMn-laurylimidazole
1-laurylimidazole
1-dodecliMidazole
N-DODECYLIMIDAZOLE
1-DODECYLIMIDAZOLE
1-dodecyl-imidazol
1-dodecyl-1h-imidazol
1-Dodecylimidazole,97%
1-Dodecylimidazole,95%
所屬類別
生物化工：抑制劑物理化學(xué)性質(zhì)
熔點(diǎn)69.5-70.5 °C(Solv: ethyl acetate (141-78-6))
沸點(diǎn)146 °C (0.5 mmHg)
密度0.9624 (rough estimate)
蒸氣壓0.009Pa at 20℃
折射率1.5312 (estimate)
儲(chǔ)存條件Refrigerator
溶解度可溶于氯仿（少許）、甲醇（少許）
酸度系數(shù)(pKa)7.08±0.10(Predicted)
形態(tài)液體
顏色透明黃色
LogP3.56-5.5 at pH5-9
表面張力45mN/m at 20mg/L and 20℃
EPA化學(xué)物質(zhì)信息1H-Imidazole, 1-dodecyl- (4303-67-7)
安全數(shù)據(jù)
1-十二烷基咪唑價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | 38170 | 1-十二烷基咪唑 1-dodecylimidazole, 97%, Thermo Scientific Chemicals | 4303-67-7 | 1g | 1115元 |
| 2024/11/08 | XW02430367704 | 1-十二烷基咪唑 | 4303-67-7 | 25G | 1543元 |
| 2024/11/08 | HY-138540 | 1-十二烷基咪唑 1-Dodecylimidazole | 4303-67-7 | 500mg | 100元 |
常見問題列表
生物活性
1-Dodecylimidazole (N-Dodecylimidazole) 是一種溶酶體活性洗滌劑和細(xì)胞毒性劑。1-Dodecylimidazole 通過其在溶酶體中的酸依賴性積累、溶酶體膜的破壞和半胱氨酸蛋白酶釋放到細(xì)胞質(zhì)中而導(dǎo)致細(xì)胞死亡。1-Dodecylimidazole 具有降膽固醇和廣譜抗真菌活性。體外研究
N-dodecylimidazole, an acid activated detergent with a pKa of 6.3, has been shown to be cytotoxic to cells in culture. N-dodecylimidazole displayed extracellular pH (pHe)-dependent cytotoxicity against EMT-6 and MGH U1 cells. cell killing was dose dependent and was 100-fold greater at pHe 6.0 than pHe 7.0.
體內(nèi)研究
The hypocholesterolaemic activity of 1-dodecylimidazole results in part from the inhibition of cholesterol biosynthesis at the level of 2,3-oxidosqualene sterol cyclase.
1-dodecylimidazole (150 mg/kg body wt; by stomach tube; daily for 10 days) has lower serum cholesterol concentrations than control rats.
| Animal Model: | Male rats |
| Dosage: | 150 mg/kg body wt |
| Administration: | By stomach tube; daily for 10 days |
| Result: | Had significantly lower serum cholesterol concentrations than untreated animals. |