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42464-96-0

中文名稱 5-氨基-1-甲基喹啉-1-鎓碘化物
英文名稱 NNMTi
CAS 42464-96-0
更新日期 2024/12/24 17:18:34
42464-96-0 結(jié)構(gòu)式 42464-96-0 結(jié)構(gòu)式

基本信息

中文別名
5-氨基-1甲基喹啉碘化物
5-氨基-1-甲基喹啉碘代物
5-氨基-1-甲基喹啉-1-碘化物
英文別名
NNMTi
5-amino-1MQ
5-Amino-1methylquinolinium iodide
5-amino-1-methylquinolin-1-ium iodide
所屬類別
醫(yī)藥中間體:喹啉類化合物

物理化學(xué)性質(zhì)

熔點(diǎn)213-214 °C
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
形態(tài)Solid
顏色Brown to reddish brown

安全數(shù)據(jù)

上下游產(chǎn)品信息

常見問題列表

生物活性
NNMTi 是一種有效的煙酰胺 N -甲基轉(zhuǎn)移酶 (NNMT) 的抑制劑 (IC50=1.2 μM),可選擇性地結(jié)合 NNMT 底物結(jié)合位點(diǎn)殘基。NNMTi 能促進(jìn)體外成肌細(xì)胞分化,增強(qiáng)老年小鼠肌肉干細(xì)胞融合和再生能力。
體外研究

NNMTi (10-30 μM; 96 hours) produces a concentration-related increase in myoblast differentiation on C2C12 myoblast differentiation. 30 μM NNMTi results in 18% MHC-positive myotube nuclei, representing a 45% increase in the extent of myoblast differentiation compared to untreated differentiating myoblasts (12% MHC-positive myotube nuclei).

體內(nèi)研究

NNMTi (subcutaneous (SC) injection; 5 mg/kg and 10 mg/kg; 2 weeks (1 week pre-injury and 1 week post-injury)) has an effect on muscle regeneration after injury, it results in 60% and 75% higher incidence of proliferating/active muSCs at 5 mg/kg and 10 mg/kg, respectively. The relative numbers of fibers with an EdU + myonucleus increased 40% and 48% with NNMTi treatment at 5 mg/kg and 10 mg/kg, respectively. The odds ratio of fused myonuclei for control are 0.58 and 0.53 times the odds at the low and high NNMTi dose, respectively.NNMTi (subcutaneous injection; 10 mg/kg; 1 week) produces no systemic toxicity in mice, the levels of the glucose, cholesterol, plasma proteins, and electrolytes between control and NNMTi-treated samples show no difference in mice. 1-week post-injury daily repeat-dosing of NNMTi is well tolerated with no untoward systemic toxicity or behavioral implications in aged mice.

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