40709-76-0
CAS
40709-76-0
40709-76-0 結(jié)構(gòu)式
常見問題列表
生物活性
RX 67668 是一種有效的膽堿酯酶 (cholinesterase) 抑制劑，對乙酰膽堿酯酶 (AChE) 和丁酰膽堿酯酶的 IC50 均為 5 μM。RX 67668 可以逆轉(zhuǎn) D-微管神經(jīng)素引起的神經(jīng)肌肉阻滯。RX 67668 是一種肌肉松弛劑，可用于緩解骨骼肌疲勞的。靶點
IC50: 5 μM (acetylcholinesterase) and 5 μM (butyrylcholinesterase)
體內(nèi)研究
RX 67668 (1-4 mg/kg; i.p.) reduces by half the dose of methacholine necessary to produce red tears, whilst RX 67668 (7-2 mg/kg s.c.) is necessary to reduce the pupil diameter of the mouse to 50% of the control value.
Rat anterior tibialis preparation of the cat tibialis preparation demonstrates that RX 67668 (0.3-1.0 mg/kg; i.v.) is effective in reversing tubocurarine-induced muscle blockade.