3854-04-4
中文名稱
Oxotremorine M
英文名稱
trimethyl-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]azanium:iodide
CAS
3854-04-4
分子式
C11H19IN2O
分子量
322.186
MOL 文件
3854-04-4.mol
更新日期
2024/10/24 11:25:04
3854-04-4 結(jié)構(gòu)式
基本信息
中文別名
碘化氧化震顫素M 英文別名
CPD3509Oxotremorine M (iodide)
trimethyl-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]azanium:iodide
物理化學(xué)性質(zhì)
儲存條件Desiccate at -20°C
溶解度DMSO : 125 mg/mL (387.97 mM; Need ultrasonic)
形態(tài)粉末
顏色Light yellow to yellow
水溶解性溶于水至100mM
常見問題列表
生物活性
Oxotremorine M iodide 是一種有效的，非選擇性毒蕈堿型乙酰膽堿受體 (mAChR) 激動劑。Oxotremorine M iodide 通過毒蕈堿受體依賴和獨(dú)立機(jī)制增強(qiáng) NMDA 受體。體外研究
Oxotremorine M iodide (0.1, 0.3, 1, 3, 10, 30 μM) inhibits KCNQ2/3 currents in the concentration-dependence.
Oxotremorine M iodide elicits a robust phosphoinositide response characterized with an EC
50
of 0.22 μM. Oxotremorine M iodide has EC
50
s of 0.36, 0.52, 1.62, and 1.48 μM for wild-type, M2, M3, and M2/M3 knockout mice, respectively.
體內(nèi)研究
Oxotremorine M iodide (0.5 mg/kg; s.c.) increases Ddopamine (DA) release in the medial prefrontal cortex (mPFC) and has no effect in the nucleus accumbens (NAC) in male sprague-dawley albino rats weighing 250-350 g.