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38520-57-9

中文名稱 N-乙酰-L-胱氨酸
英文名稱 N-Acetyl-L-cysteinamide
CAS 38520-57-9
分子式 C5H10N2O2S
分子量 162.21
MOL 文件 38520-57-9.mol
更新日期 2024/11/05 14:08:08
38520-57-9 結(jié)構(gòu)式 38520-57-9 結(jié)構(gòu)式

基本信息

中文別名
N-乙酰半胱氨酸酰胺
乙酰半胱氨酸雜質(zhì)14
乙?;?L-半胱氨酸
N-乙酰-L-胱氨酸
N-乙?;?L-半胱氨酰胺
(2R)-2-乙酰氨-3-硫丙酰胺
(R) -2-乙酰氨基-3-巰基丙酰胺
英文別名
AD4
NACA
100951
acetylcysteinamide
N-ACETYL-L-CYSTINE
N-acetylcysteine amide
N-Acetyl-L-cysteinamide
N-acetyl-L-Cysteine amide
Acetylcysteine Impurity 14
(R)-2-acetaMido-3-MercaptopropanaMide
所屬類別
生物化工:氨基酸及其衍生物

物理化學(xué)性質(zhì)

熔點147-149 °C(Solv: ethanol (64-17-5))
沸點441.0±40.0 °C(Predicted)
密度1.226±0.06 g/cm3(Predicted)
儲存條件2-8°C
溶解度H2O:≥20mg/mL
酸度系數(shù)(pKa)9.21±0.10(Predicted)
形態(tài)凍干粉
顏色白色至灰白色
InChIInChI=1S/C5H10N2O2S/c1-3(8)7-4(2-10)5(6)9/h4,10H,2H2,1H3,(H2,6,9)(H,7,8)/t4-/m0/s1
InChIKeyZLCOWUKVVFVVKA-GDVGLLTNSA-N
SMILESC(N)(=O)[C@@H](NC(C)=O)CS

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險性描述H302
危險品標志Xn
危險類別碼22
WGK Germany3
N-乙酰-L-胱氨酸價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/11/08HY-110256N-乙酰-L-胱氨酸
N-Acetylcysteine amide
38520-57-91mg363元
2024/11/08HY-110256N-乙酰-L-胱氨酸
N-Acetylcysteine amide
38520-57-95mg800元
2024/11/08S5804N-乙酰-L-胱氨酸
N-Acetylcysteine amide
38520-57-95mg795.33元

常見問題列表

生物活性
N-acetylcysteine amide是一種能穿透細胞膜的抗氧化劑,具有消炎活性,能夠調(diào)節(jié)NF-κB的激活、HIF-1α和ROS。
靶點
TargetValue
NF-κB
()
HIF-1α
()
ROS
()
體外研究

N-Acetylcysteine amide shows no obvious effect on the viability of H9c2 cells treated with doxorubicin (DOX) at < 1 mM, but causes significant cytotoxicity at 10-20 mM. N-Acetylcysteine amide (750 μM) reduces the ROS levle and lipid peroxidation induced by DOX, and restores GSH/GSSG ratio and activities of antioxidant enzymes, such as catalase (CAT), gluthathione peroxidase (GPx), gluthathione reductase (GR). N-Acetylcysteine amide (1 mM) protects the human brain microvascular endothelial (HBMVEC) from methamphetamine (METH)- induced cell death.

體內(nèi)研究

N-Acetylcysteine amide has increased CNS bioavailability. N-Acetylcysteine amide (150 mg/kg, i.p.) improves cortical sparing and functional outcome, reduces oxidative stress, improves mitochondrial bioenergetics, and maintains mitochondrial glutathione content following traumatic brain injury (TBI) in rats.

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