375345-95-2
中文名稱
MIBAMPATOR
英文名稱
MibaMpator
CAS
375345-95-2
分子式
C21H30N2O4S2
分子量
438.6
MOL 文件
375345-95-2.mol
更新日期
2024/12/23 17:39:04
375345-95-2 結(jié)構(gòu)式
基本信息
中文別名
化合物 T15820化合物MIBAMPATOR
英文別名
CS-1234LY 451395
MibaMpator
MIBAMPATOR
LY 451395
LY-451395
2-Propanesulfonamide, N-[(2R)-2-[4'-[2-[(methylsulfonyl)amino]ethyl][1,1'-biphenyl]-4-yl]propyl]-
[(2R)-2-[4-[4-[2-[(Methylsulfonyl)amino]ethyl]phenyl]phenyl]propyl][(1-methylethyl)sulfonyl]amine
所屬類別
生物化工：激動(dòng)劑抑制劑物理化學(xué)性質(zhì)
沸點(diǎn)609.4±65.0 °C(Predicted)
密度1.205±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)11.05±0.40(Predicted)
形態(tài)粉末
顏色White to off-white
常見問題列表
生物活性
Mibampator (LY451395)是AMPA受體高選擇性增強(qiáng)劑。靶點(diǎn)
AMPA receptor.
體內(nèi)研究
Incubation of Mibampator (LY451395) with Actinoplanes missouriensis NRRL B3342 generated several metabolites that were previously detected in the in vivo metabolism studies of the preclinical species [1]. LY404187 and Mibampator (LY451395) reverses the central effects of an acutely intoxicating dose of ethanol in the rat. Mibampator (LY451395) significantly and dose-dependently reversed ethanol-induced deficits in both motor coordination and disruptions in an operant task where animals were trained to press a lever for food reward [2].