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364779-15-7

中文名稱 人參皂苷 RK3
英文名稱 Ginsenoside Rk3
CAS 364779-15-7
分子式 C36H60O8
分子量 620.87
MOL 文件 364779-15-7.mol
更新日期 2024/10/21 09:37:39
364779-15-7 結(jié)構(gòu)式 364779-15-7 結(jié)構(gòu)式

基本信息

中文別名
人參皂甙RK3
人參皂苷 RK3
人參皂苷RK3對(duì)照品
人參皂苷RK3(標(biāo)準(zhǔn)品)
人參皂苷RK3,R1=葡萄糖
人參皂苷RK3(人參皂甙RK3)
英文別名
Ginsenoside Rk3
Ginsenoside Rk3 standard
β-D-Glucopyranoside, (3β,6α,12β)-3,12-dihydroxydammara-20,24-dien-6-yl
所屬類別
生物化工:植物提取物

物理化學(xué)性質(zhì)

外觀性狀白色粉末,可溶于甲醇、乙醇、DMSO等有機(jī)溶劑,來源于人參。
沸點(diǎn)722.4±60.0 °C(Predicted)
密度1.20±0.1 g/cm3 (20 ºC 760 Torr)
儲(chǔ)存條件4°C, protect from light
溶解度Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
酸度系數(shù)(pKa)12.91±0.70(Predicted)
形態(tài)粉末
顏色White to off-white

應(yīng)用領(lǐng)域

用途1
用于含量測(cè)定/鑒定/藥理實(shí)驗(yàn)等。
藥理藥效:可能有心血管、按腫瘤方面的活性
用途2
人參皂苷RK3存在于加工的田三七中,是常用的缺血性心臟疾病的復(fù)方制劑的主要成分。

常見問題列表

生物活性
Ginsenoside Rk3 存在于 Panax notoginseng 的根中。在 HepG2 細(xì)胞中 Ginsenoside Rk3 抑制 TNF-α 誘導(dǎo)的 NF-κB 轉(zhuǎn)錄活性, IC50 值為 14.24±1.30 μM。
靶點(diǎn)

NF-κB

14.24 μM (IC 50 , in HepG2 cells)

NF-κB

15.32 μM (IC 50 , in SK-Hep1 cell)

體外研究

Ginsenoside Rk3 exerts the strong activity inhibiting NF-κB in a dose-dependent manner. HepG2 cells are pre-treated with different ginsenosides at concentrations ranging from 0.01 to 10 μM for 1 h, and induced with TNF-α for 20 h. Ginsenoside Rk3 significantly inhibits TNF-α-induced NF-κB transcriptional activity, with an IC 50 of 14.24±1.30 μM. Ginsenoside Rk3 significantly inhibits TNF-α-induced NF-κB transcriptional activity, with an IC 50 of 15.32±0.29 μM in SK-Hep1 cells, consistent with the data from HepG2 cells. Consistent with the inhibition of NF-κB, Ginsenoside Rk3 inhibits the induction of IL8 , CXCL1 , iNOS , and ICAM1 mRNA significantly in a dose-dependent manner.

體內(nèi)研究

The inhibitory effects of Ginsenoside Rk3 (Rk3) on tumor progression are studied in vivo using a H460 xenograft model in nude mice. Compared with the control group, a significant inhibition of tumor growth (volume) is observed in the Ginsenoside Rk3-treated group. Twenty-one days after treatment initiation, tumor growth is significantly inhibited by approximately 62.99% in the mice receiving 20 mg/kg Ginsenoside Rk3, similar to the inhibitory effect observed in the 20 mg/kg Gefitinib-treated group (57.21%). Compared with the control group, tumor growth is moderately inhibited in the mice receiving 10 and 5 mg/kg Ginsenoside Rk3, with inhibition rates of 32.54% and 11.84%, respectively.

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