35882-85-0
中文名稱
26,27-Dinorergost-5-ene-3β,24-diol
英文名稱
26,27-Dinorergost-5-ene-3β,24-diol
CAS
35882-85-0
分子式
C26H44O2
分子量
388.63
MOL 文件
35882-85-0.mol
35882-85-0 結構式
基本信息
中文別名
化合物 T24787 英文別名
SGE-20126,27-Dinorergost-5-ene-3β,24-diol
24,24-dimethyl-cholene-(5)-diol-(3β.24)
(3S,8S,9S,10R,13R,14S,17R)-17-[(2R)-5-hydroxy-5-methylhexan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
應用領域
用途一
SGE-201 is a potent allosteric modulator of N-methyl-D-aspartate receptors. SGE-201 is an analogue of an endogenous oxysterol. bSGE-201 increased the actions of memantine and ketamine on phasic excitatory post-synaptic currents, but neither revealed underlying pharmacodynamic differences. SGE-201 accelerated the re-equilibration of blockers during voltage jumps. SGE-201 also unmasked differences among the blockers in neuronal networks - measured either by suppression of activity in multi-electrode arrays or by neuroprotection against a mild excitotoxic insult.