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3546-41-6

中文名稱 撲蟯靈
英文名稱 PYRVINIUM PAMOATE
CAS 3546-41-6
分子式 C75H70N6O6
分子量 1151.39
MOL 文件 3546-41-6.mol
更新日期 2025/02/04 08:46:06
3546-41-6 結(jié)構(gòu)式 3546-41-6 結(jié)構(gòu)式

基本信息

中文別名
撲蟯靈
吡維銨
吡維氯銨
恩波吡維銨
恩波酸吡維銨
雙羥萘酸撲蟯寧 USP標準品
WNT抑制劑(PYRVINIUM PAMOATE)
雙[6-(二甲基氨基)-2-[2-(2,5-二甲基-1-苯基吡咯-3-基)乙烯基]-1-甲基喹啉]4,4'-亞甲基雙[3-羥基-2-萘甲酸酯
英文別名
tru
povan
pyrcon
Poquil
povanyl
altolat
alnoxin
molevac
pamovin
sn-4395
所屬類別
原料藥:驅(qū)腸蟲藥

物理化學性質(zhì)

熔點210-215° (softens at 190°)
沸點829.27°C (rough estimate)
密度1.0104 (rough estimate)
折射率1.6400 (estimate)
儲存條件room temp
溶解度二甲基亞砜:>10mg/mL
形態(tài)粉末
顏色紅色
EPA化學物質(zhì)信息Pyrvinium pamoate (3546-41-6)

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS08
警示詞警告
危險品標志Xn
危險類別碼20/21/22-36/37/38-40
安全說明26-36
WGK Germany3
海關編碼2933492250
撲蟯靈價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2025/02/08HY-A0293撲蟯靈
Pyrvinium pamoate
3546-41-65 mg343元
2025/02/08HY-A0293撲蟯靈
Pyrvinium pamoate
3546-41-610mg550元
2025/02/08HY-A0293撲蟯靈
Pyrvinium pamoate
3546-41-650mg983元

常見問題列表

生物活性
Pyrvinium是一種驅(qū)蟲劑,對蟯蟲有效。
體外研究

Pyrvinium pamoate (0-500 nM) inhibits proliferation of MCF-7 (luminal), MDA-MB-231 (claudin-low), MDA-MB-468 (basal-like) and SkBr3 (HER2-OE) cells in a dose-dependent manner, with IC 50 value of 1170±105.0 nM against MDA-MB-231 cell line. Pyrvinium pamoate significantly inhibits self-renewal and proliferation of BCSCs, and suppresses BCSC population with a distinct phenotype. Pyrvinium pamoate significantly decreases average expression levels of FZD1, FZD10, WNT1, WNT7B, CTNNB1, MYC, and LRP5 at transcriptional level. Moreover, Pyrvinium pamoate also efficiently down-regulates the expression of other stemness genes including ALDH1, CD44 and ABCG2. Pyrvinium pamoate blocks colon cancer cell growth in vitro in a dose-dependent manner with great differences in the inhibitory concentration (IC 50 ), ranging from 0.6 to 65 μM for colon cancer cells with mutations in WNT signaling. Pyrvinium pamoate decreases messenger RNA (mRNA) and protein levels of known WNT target genes as c-MYC and thereby led to the induction of p21. Pyrvinium pamoate ultimately inhibits Wnt signalling despite its lack of efficacy on CK1. Pyrvinium pamoate imposes specific toxicity on cardiac fibroblasts in ischemia (IC 50 =9.5 nM). The cytotoxic effect of Pyrvinium pamoate on cardiac fibroblasts specifically under glucose- and glutamine-deficient condition.

體內(nèi)研究

In the xenograft model, Pyrvinium pamoate (500 nM)-pretreatment strongly delays tumor size and tumor weight, and the tumor volume is markedly decreased.

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