353793-07-4
英文名稱
2-Quinoxalineacetamide, 1,2,3,4-tetrahydro-6,7-dimethyl-N-[4-(4-morpholinyl)phenyl]-3-oxo-
CAS
353793-07-4
分子式
C22H26N4O3
分子量
394.47
MOL 文件
353793-07-4.mol
353793-07-4 結(jié)構(gòu)式
應(yīng)用領(lǐng)域
用途一
Z640 an aPKC agonist. Z640 was further confirmed as a non?selective aPKC agonist that can activate the kinase activity of both PKCι and PKCζ. In the cell?based assay, Z640 was found to protect neuronal cell lines from amyloid?β (Aβ) oligomer?induced cell death by reducing reactive oxygen species production and restore mitochondrial function. In addition, Z640 could reduce Aβ40 generation in a dose?dependent manner and shift amyloid precursor protein processing towards the non?amyloid pathway