351424-20-9
中文名稱
化合物TRPM4-IN-1
英文名稱
4-chloro-2-(2-(2-chlorophenoxy)acetamido)benzoic acid
CAS
351424-20-9
分子式
C15H11Cl2NO4
分子量
340.16
MOL 文件
351424-20-9.mol
351424-20-9 結構式
基本信息
中文別名
化合物TRPM4-IN-1 英文別名
TRPM4-IN-1TRPM4-IN-5
CBA (TRPM4-IN-5)
TRPM4 inhibitor 5
4-chloro-2-(2-(2-chlorophenoxy)acetamido)benzoic acid
4-Chloro-2-[[2-(2-chlorophenoxy)acetyl]amino]benzoic acid
Benzoic acid, 4-chloro-2-[[2-(2-chlorophenoxy)acetyl]amino]-
TRP Channel,Transient receptor potential channels,non-selective,TRPM4IN1,diseases,TRPM4,inhibit,Inhibitor,TRPM-4-IN-1,TRPM4 IN 1,cancer,cation,cardiac,channel,prostate,calcium-activated
常見問題列表
生物活性
TRPM4-IN-1 (CBA) 是一種有效的、選擇性的陽離子通道 TRPM4 抑制劑，其 IC50 為 1.5 μM。TRPM4-IN-1 可用于心臟病和前列腺癌的研究。體外研究
TRPM4-IN-1 (compound 5) is a potent and selective inhibitor of TRPM4 current in TRPM4 overexpressed HEK293 cells.
TRPM4-IN-1 reversibly blocks endogenous TRPM4 currents in LNCaP (prostate cancer) cells.
TRPM4-IN-1 (50 μM; Overnight) restores functional expression of A432T, a loss‐of‐expression TRPM4 variant.
Western Blot Analysis
| Cell Line: | HEK293 cells |
| Concentration: | 50 μM |
| Incubation Time: | Overnight |
| Result: | Partial rescued the total and surface expression of A432T. |