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351344-10-0

中文名稱 METHYLLYCACONITINE CITRATE
英文名稱 Methyllycaconitine (citrate)
CAS 351344-10-0
分子式 C43H58N2O17
分子量 874.93
MOL 文件 351344-10-0.mol
351344-10-0 結(jié)構(gòu)式 351344-10-0 結(jié)構(gòu)式

基本信息

中文別名
甲基牛扁亭檸檬酸鹽

物理化學(xué)性質(zhì)

儲(chǔ)存條件Desiccate at -20°C
溶解度可溶于水
形態(tài)固體
顏色White to yellow

常見(jiàn)問(wèn)題列表

生物活性
Methyllycaconitine citrate 是 α7 神經(jīng)元煙堿型乙酰膽堿受體 (α7nAChR) 的特異性拮抗劑。
靶點(diǎn)

α7nAChR

體外研究

Pretreatment with 5 and 10 μM Methyllycaconitine citrate (MLA) inhibits the decreased cell viability induced by Aβ 25-35 . Cell viability does not decrease after exposure to Methyllycaconitine citrate (2.5, 5, 10, 20 μM). Aβ 25-35 treatment increases LC3-II levels, which is inhibited by administration of Methyllycaconitine citrate. Methyllycaconitine citrate also inhibits Aβ-induced autophagosome accumulation in SH-SY5Y cells. Flow cytometry also demonstrates decreased MDC-labeled vacuoles with Methyllycaconitine citrate treatment.

體內(nèi)研究

Methyllycaconitine citrate (MLA) (6 mg/kg) given alone intraperitoneally does not cause climbing behavior when compare with the saline group. Pretreatment with Methyllycaconitine citrate significantly inhibits methamphetamine (METH)-induced climbing behavior, by about 50%. Methyllycaconitine citrate does not modify either basal locomotor activity or METH-induced hyperlocomotion. The METH-induced depletion of dopamine neuron terminals is attenuated in mice pretreated with Methyllycaconitine citrate (250±43 fmol/mg, n=7). A direct effect of Methyllycaconitine citrate on body temperature is ruled out because Methyllycaconitine citrate does not affect basal body temperature (37.0±0.5°C, n=5) or reduce the METH-induced hyperthermia (38.2±0.4°C, n=6, MLA+METH group, n.s. versus METH group).

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