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3475-39-6

中文名稱 1,1,3-三溴丙酮
英文名稱 1,1,3-Tribromoacetone
CAS 3475-39-6
分子式 C3H3Br3O
分子量 294.77
MOL 文件 3475-39-6.mol
更新日期 2024/12/23 16:05:57
3475-39-6 結(jié)構(gòu)式 3475-39-6 結(jié)構(gòu)式

基本信息

中文別名
三溴丙酮
1,1,1三溴丙酮
1,1,3-三溴丙酮
1,1,3-三溴丙酮,甲氨蝶呤中間體
英文別名
JACS-3475-39-6
1,1,3-TribromoAceton
1,1,3-tribromoacetone
1,1,3-Tribromopropan-2-one
2-Propanone,1,1,3-tribromo-
所屬類別
化學(xué)試劑:氘代試劑

物理化學(xué)性質(zhì)

熔點(diǎn)28-29 °C
沸點(diǎn)114-116 °C(Press: 14 Torr)
密度2.561±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO : 100 mg/mL (339.25 mM; Need ultrasonic)
形態(tài)Liquid
顏色Colorless to light yellow

常見問(wèn)題列表

生物活性
1,1,3-Tribromoacetone 是甲氨蝶呤 (HY-14519) 的雜質(zhì)。Methotrexate (Amethopterin) 是一種抗代謝 (antimetabolite) 和抗葉酸劑 (antifolate),可抑制二氫葉酸還原酶,從而防止葉酸轉(zhuǎn)化為四氫葉酸并抑制 DNA 合成。
體內(nèi)研究

Methotrexate (Amethopterin) reduces thymus and spleen indices of mice. Methotrexate markedly decreases white blood cells, thymic and splenic lymphocytes at dose ≥5 mg/kg. However, there is a significant difference between the treatment plus control group and the model group (p<0.01). The combination of grape seed proanthocyanidins and Siberian ginseng eleutherosides obviously diminishes the effects of Methotrexate exposure on indices of thymus and spleens in mice. Methotrexate (MTX) (2 mg/kg; i.p.; once in a week for 5 weeks) is effective in Freund's complete adjuvant-induced arthritis. The combination of Methotrexate (1 mg/kg; i.p.; once in a week for 5 weeks) and Curcumin (30 mg/kg and 100 mg/kg, thrice a week for 5 weeks; i.p.) shows a significant anti-arthritic action and protection from hematological toxicity.

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