32908-73-9
基本信息
肥大細(xì)胞脫粒肽
蜜蜂肥大細(xì)胞脫粒肽
isulfide)
MCD PEPTIDE
Peptide 401
IKCNCKRHVIKPHICRKICGKN-NH2
MCD PEPTIDE (APIS MELLIFERA)
MAST CELL DEGRANULATING PEPTIDE
MAST CELL DEGRANULATING (MCD) PEPTIDE
mastcelldegranulatingpeptide(honeybee)
MCD-PEPTIDE (HONEYBEE, APIS MELLIFERA)
物理化學(xué)性質(zhì)
報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
2024/11/08 | HY-12537 | MAST CELL DEGRANULATING PEPTIDE Peptide 401 | 32908-73-9 | 500μg | 1350元 |
2024/11/08 | HY-12537 | MAST CELL DEGRANULATING PEPTIDE Peptide 401 | 32908-73-9 | 1mg | 2200元 |
2024/11/08 | HY-12537 | MAST CELL DEGRANULATING PEPTIDE Peptide 401 | 32908-73-9 | 5mg | 5500元 |
常見(jiàn)問(wèn)題列表
serotonin
|
Histamine Receptor
|
Peptide 401 substantially inhibits the oedema provoked by subplantar injection of carrageenin or intra-articular injection of turpentine in the rat. The ED 50 of 401 is c. 0.1 mg/kg. The anti-inflammatory effect is assessed by measurement of the increased 125 I-albumin content of an injected site in comparison with an uninjected contralateral site. Peptide 401 also suppresses the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, bradykinin, 5-hydroxytryptamine (5-HT), and prostaglandins). Peptide 401 (MCD peptide) contains 22 residues and occurs in the venom of the common European honey bee to the extent of about 2% by weight . It has powerful anti-inflammatory activity (at doses as low as 0.1 mg/kg) in a variety of animal models, i.e., hind paw oedema in the rat induced by carrageenin or turpentine, adjuvant arthritis in the rat, and increased skin permeability in the rat resulting from subcutaneous injection of bradykinin, prostaglandin E1 kallikrein, histamine and 5- hydroxytryptamine (5-HT). It has a powerful degranulating effect on mast cells and involves the release of histamine and other pharmacologically active agents.