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31098-42-7

中文名稱 氨磷汀硫化物
英文名稱 2-(3-aminopropylamino)ethanethiol
CAS 31098-42-7
分子式 C5H14N2S
分子量 134.24
MOL 文件 31098-42-7.mol
31098-42-7 結(jié)構(gòu)式 31098-42-7 結(jié)構(gòu)式

基本信息

中文別名
氨磷汀硫化物
英文別名
WR 1065
2-(3-aminopropylamino)ethanethiol
Ethanethiol,2-[(3-aminopropyl)amino]-
N-(2-Mercaptoethyl)-1,3-propanediamine
2-((3-Aminopropyl)amino)ethyl hydrosulfide

物理化學(xué)性質(zhì)

沸點(diǎn)218.6±15.0 °C(Predicted)
密度0.975±0.06 g/cm3(Predicted)
儲(chǔ)存條件4°C, protect from light, stored under nitrogen
溶解度DMSO: < 1 mg/mL (insoluble or slightly soluble)
酸度系數(shù)(pKa)10.00±0.10(Predicted)
形態(tài)固體
顏色白色
水溶解性Water: 250 mg/mL (1862.34 mM)

常見問題列表

生物活性
Amifostine thiol (WR-1065) 是細(xì)胞保護(hù)劑 Amifostine (HY-B0639) 的活性代謝物。Amifostine thiol 是一種具有輻射防護(hù)能力的細(xì)胞保護(hù)劑。Amifostine thiol 通過 JNK 依賴的信號(hào)通路激活 p53。
靶點(diǎn)

p53

體外研究

Amifostine thiol can reduce both the direct and delayed detrimental effects of both high and low-LET radiation exposures.
Amifostine thiol attenuates both the DNA damage and the G1-phase arrest induced by radiation.
Amifostine thiol (4 mM; 30 minutes) protects RKO36 cells from chromosomal damage and death induced by ionizing radiation.
Amifostine thiol (4 mM; 30 minutes) protects irradiated RKO36 cells from delayed genomic instability.
Amifostine thiol is cytotoxic to RKO36 cells at milimolar concentrations, especially after continuous treatment.
Amifostine thiol at 40 μM protects RKO36 cells from delayed genomic instability but not from cell death and immediate chromosomal damage.
Amifostine thiol activates JNK resulting in the phosphorylation of p53 at threonine 81.
Amifostine thiol affects phosphorylation of topoisomerase IIα leading to changes in enzyme activity and cell cycle progression in CHO AA8 cells.

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