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293762-45-5

中文名稱 10G, 50G, 100G, 1KG
英文名稱 RO 90-7501
CAS 293762-45-5
分子式 C20H16N6
分子量 340.388
MOL 文件 293762-45-5.mol
293762-45-5 結(jié)構(gòu)式 293762-45-5 結(jié)構(gòu)式

基本信息

中文別名
化合物 T16773
英文別名
RO90-7501
RO 907501
2'-(4-aMinophenyl)-1H,3'H-2,5'-bibenzo[d]iMidazol-6-aMine

物理化學(xué)性質(zhì)

儲(chǔ)存條件Store at +4°C
溶解度二甲基亞砜：20 毫克/毫升
形態(tài)固體
顏色棕色

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H315-H319-H335
危險(xiǎn)品標(biāo)志Xi
危險(xiǎn)類別碼36/37/38
安全說明26-36/37
WGK Germany3

常見問題列表

生物活性
Ro 90-7501 是一種淀粉樣 β42 (Aβ42) 原纖維組裝抑制劑，可降低 Aβ42 誘導(dǎo)的細(xì)胞毒性 (EC50 為 2 μM)。Ro 90-7501 抑制 ATM 磷酸化和 DNA 修復(fù)。RO 90-7501選擇性增強(qiáng) TLR3 和 RLR 配體誘導(dǎo)的 IFN-β 基因表達(dá)和抗病毒反應(yīng)。Ro 90-7501 還以 TPR 依賴性方式抑制蛋白磷酸酶 5 (PP5)，并對(duì)宮頸癌細(xì)胞具有顯著的放射增敏作用。
靶點(diǎn)

Amyloid β42

ATM

Protein phosphatase 5

Apoptosis

體外研究

Ro 90-7501 significantly enhances radiosensitivity compared with control HeLa and ME-180 cells. Ro 90-7501 significantly increases apoptosis and impaired cell cycle after irradiation. Ro 90-7501 suppresses the phosphorylation of ATM and its downstream proteins, such as H2AX, Chk1, and Chk2, after irradiation.
RO 90-7501, itself affects neither IFN-β nor NFκB promoter activity, but significantly enhances poly I:C-induced IFN-β promoter activation and inhibits the activation of NFκB in a dose-dependent manner. Treatment of cells with RO 90-7501 significantly enhances the antiviral activity of poly I:C.

體內(nèi)研究

Ro 90-7501 (5 μg/g; intraperitoneal injection; daily; for 21 days; female BALB/c nude mice) treatment significantly delays tumor growth and significantly decreases tumor volume.

Animal Model: Female BALB/c nude mice (8-week-old) with HeLa cells under irradiation
Dosage: 5 μg/g
Administration: Intraperitoneal injection; daily; for 21 days
Result: Tumor growth was significantly delayed in the combination group. Tumor volume was also significantly decreased in the irradiation group.
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