288628-05-7
288628-05-7 結(jié)構(gòu)式
基本信息
6-氧代-6,7,8,9,10,11-六氫環(huán)庚[C] [1]苯并吡喃-3-基磺酸鹽
ST-64667
BN 83495
STX64667
STX 64667
Irosustat
Irosustat(STX64)
COUMATE. Irosustat.
DSLPMJSGSBLWRE-UHFFFAOYSA-N
STX64 - BN83495 | Irosustat | 667 Coumate
物理化學(xué)性質(zhì)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2024/11/08 | HY-14586 | 6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate Irosustat | 288628-05-7 | 5mg | 1000元 |
| 2024/11/08 | HY-14586 | 6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate Irosustat | 288628-05-7 | 10 mM * 1 mLin DMSO | 1100元 |
| 2024/11/08 | HY-14586 | 6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate Irosustat | 288628-05-7 | 10mg | 1502元 |
常見問題列表
| Target | Value |
|
STS
() | 8 nM |
Irosustat (667 COUMATE) is a potent steroid sulfatase inhibitor, with an IC 50 of 8 nM. Irosustat (667 COUMATE) inhibits steroid sulphatase (STS) activity in MCF-7 cells with an IC 50 of 0.2 nM, but has no effect on the morphology or proliferation of MCF-7 cells at 10 μM.
Irosustat potently inhibits rat liver, with inhibition of >90% when at a 1 mg/kg concentration. Irosustat (2 mg/kg, p.o. for 5 d) blocks the uterine growth stimulated by oestrone sulfate (E1S) in ovariectomized rats. In addition, Irosustat (2, 10 mg/kg, p.o.) plus E1S dose-dependently decreases the growth of NMU-induced mammary tumors in ovariectomized rats. Irosustat (667 COUMATE; 10 mg/kg, p.o.) shows 97.9 ± 0.06% inhibition on steroid sulphatase (STS) activity in rat liver.