2765218-56-0
中文名稱
5-PHENYL-N-(3-(THIAZOL-2-YL)PROPYL)ISOXAZOLE-3-CARBOXAMIDE
英文名稱
3-Isoxazolecarboxamide, 5-phenyl-N-[3-(2-thiazolyl)propyl]-
CAS
2765218-56-0
分子式
C16H15N3O2S
分子量
313.37
MOL 文件
2765218-56-0.mol
更新日期
2024/11/07 22:40:25
2765218-56-0 結(jié)構(gòu)式
基本信息
中文別名
5-苯基-N-[3-(2-噻唑基)丙基]異噁唑-3-甲酰胺5-PHENYL-N-(3-(THIAZOL-2-YL)PROPYL)ISOXAZOLE-3-CARBOXAMIDE
英文別名
3-Isoxazolecarboxamide, 5-phenyl-N-[3-(2-thiazolyl)propyl]-物理化學(xué)性質(zhì)
沸點(diǎn)559.1±45.0 °C(Predicted)
密度1.266±0.06 g/cm3(Predicted)
酸度系數(shù)(pKa)13.06±0.46(Predicted)
形態(tài)Solid
顏色White to off-white
應(yīng)用領(lǐng)域
用途一
PY-60 is a novel activator of YAP, promoting expansion of epidermal keratinocytes ex vivo and in vivo, targeting ANXA2 to activate YAP, activating a robust, YAP- dependent transcriptional program in multiple cell types. Chemical proteomics revealed the relevant target of PY-60 to be annexin A2 (ANXA2), a protein that directly associates with YAP at the cell membrane in response to increased cell density. PY-60 treatment liberates ANXA2 from the membrane, ultimately promoting a phosphatase-bound, nonphosphorylated and transcriptionally active form of YAP.