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2751530-13-7

中文名稱(chēng) Seladelpar sodium salt
英文名稱(chēng) Seladelpar sodium salt
CAS
分子式 C??H??F?NaO?S
 結(jié)構(gòu)式 結(jié)構(gòu)式

基本信息

中文別名
化合物 T12876
英文別名
Seladelpar sodium salt

物理化學(xué)性質(zhì)

形態(tài)Solid
顏色White to off-white
Seladelpar sodium salt價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱(chēng)CAS號(hào)包裝價(jià)格
2025/02/08HY-19522ASeladelpar sodium salt2751530-13-71 mg210元
2025/02/08HY-19522ASeladelpar sodium salt
Seladelpar sodium salt
2751530-13-75mg480元
2025/02/08HY-19522ASeladelpar sodium salt
Seladelpar sodium salt
2751530-13-710mM * 1mLin DMSO528元

常見(jiàn)問(wèn)題列表

生物活性
Seladelpar sodium salt (MBX-8025) 是一種具有口服活性的、選擇性的 PPARδ 激動(dòng)劑,EC50 值為 2 nM。它對(duì) PPARδ 的選擇性分別是對(duì) PPARα 和 PPARγ 的 750 和 2500 多倍。
靶點(diǎn)

PPAR-δ

2 nM (EC 50 )

體外研究

MBX-8025 is an orally active, potent (EC 50 =2 nM), and specific (750-fold and 2500-fold compared with PPARα or PPARγ receptors, respectively) PPARδ agonist being developed as a lipid-altering agent.

體內(nèi)研究

In atherogenic diet-fed Wt mice, administration of Seladelpar sodium salt reduces body weight by ~18% (P<0.05). In contrast, Seladelpar sodium salt produces minimal effect on body weight in atherogenic diet-fed foz/foz mice. Seladelpar sodium salt lowers serum alanine aminotransferase (ALT) levels in foz/foz mice (P<0.05) and similarly (but not significantly) in Wt mice. Seladelpar sodium salt normalizes serum cholesterol and decreases triglycerides in both genotypes (P<0.05). Seladelpar sodium salt abolishes hepatocyte ballooning (P<0.05) and decreases the nonalcoholic fatty liver disease (NAFLD) activity score by ~50%. Seladelpar sodium salt also significantly reduces sirius red-positive areas in foz/foz mice (P<0.05).

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