251356-45-3
251356-45-3 結(jié)構(gòu)式
基本信息
化合物 T16947
PDGFR Tyrosine Kinase Inhibitor VII - CAS 251356-45-3 - Calbiochem
(Z)-3-(2,4-Dimethyl-5-((2-oxo-6-phenylindolin-3-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid
5-[1,2-Dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoicacid
1H-Pyrrole-3-propanoic acid, 5-[(1,2-dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-
物理化學(xué)性質(zhì)
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2025/02/05 | HY-108628 | 化合物 T16947 SU16f | 251356-45-3 | 1 mg | 480元 |
| 2025/02/05 | HY-108628 | 化合物 T16947 SU16f | 251356-45-3 | 10 mM * 1 mLin DMSO | 833元 |
| 2025/02/05 | HY-108628 | 化合物 T16947 SU16f | 251356-45-3 | 5mg | 980元 |
常見(jiàn)問(wèn)題列表
|
PDGFRβ 10 nM (IC 50 ) |
PDGFR2 140 nM (IC 50 ) |
PDGFR1 2.29 μM (IC 50 ) |
SU16f (20 μM; for 8 hours) pretreatment inhibits the promoting role of GC-MSC-CM in SGC-7901 cell proliferation.
SU16f (20 μM; for 8 hours) significantly abolishes PDGFRβ activation in SGC-7901 by GC-MSC-CM. SU16f pretreatment results in the upregulation of E-cadherin and downregulation of N-cadherin, Vimentin, and α-SMA. SU16f pretreatment leads to downregulation of p-AKT, Bcl-xl, and Bcl-2 levels and upregulation of Bax expression in SGC-7901 cells by GC-MSC-CM .
Cell Proliferation Assay
| Cell Line: | SGC-7901 cells in GC-MSC/SGC-7901 co-culture system |
| Concentration: | 20 μM |
| Incubation Time: | 8 hours |
| Result: | Inhibited the promoting role of GC-MSC-CM in SGC-7901 cell proliferation. |
Western Blot Analysis
| Cell Line: | SGC-7901 cells |
| Concentration: | 20 μM |
| Incubation Time: | 8 hours |
| Result: | Significantly abolished PDGFRβ activation in SGC-7901 by GC-MSC-CM, and resulted in the upregulation of E-cadherin and downregulation of N-cadherin, Vimentin, and α-SMA. |