247912-76-1
中文名稱
脫乙基氯喹二磷酸鹽
英文名稱
Desethylchloroquine diphosphate salt
CAS
247912-76-1
分子式
C16H25ClN3O4P
分子量
389.82
MOL 文件
247912-76-1.mol
247912-76-1 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
儲(chǔ)存條件4°C, protect from light, stored under nitrogen
溶解度溶于二甲基亞砜
形態(tài)Solid
顏色White to off-white
常見(jiàn)問(wèn)題列表
生物活性
Desethyl chloroquine diphosphate 是 Chloroquine 的主要去乙基代謝產(chǎn)物。Chloroquine 是一種自噬和 toll-like receptors (TLRs) 的抑制劑。Desethyl chloroquine diphosphate 具有抗瘧原蟲(chóng)活性。靶點(diǎn)
P. falciparum
體內(nèi)研究
Intraperitoneal injections of Chloroquine are administered to wild-type and Huntington's disease (Q175/Q175) mice. LC-MS/MS is used to compare the levels Chloroquine and its metabolites in blood, brain and muscle tissue. Concentrations of Chloroquine are lower (5-15M), but more stable in brain tissue compared to blood or muscle between 4 and 24 hours after the last dose. Levels of the active Chloroquine metabolite Desethyl chloroquine decreased in muscle and blood over the 24 hour post-injection period, while brain Desethyl chloroquine levels are lower and rose slightly over the same time frame.